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Gene Information
Gene symbol: CASP3
Gene name: caspase 3, apoptosis-related cysteine peptidase
HGNC ID: 1504
Synonyms: CPP32, CPP32B, Yama, apopain
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BAX | 1 hits |
| 2 | BCL2 | 1 hits |
| 3 | FADD | 1 hits |
| 4 | FAS | 1 hits |
| 5 | NOX5 | 1 hits |
| 6 | PI3 | 1 hits |
| 7 | PTGS2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16380497 | Increased extracellular glucose (30 mmol/l) rapidly stimulated generation of intracellular reactive oxygen species (ROS) through NADPH oxidase and mitochondrial pathways and led to activation of proapoptotic p38 mitogen-activated protein kinase and caspase 3 and to apoptosis of conditionally immortalized podocytes in vitro. |
| 2 | 20827429 | ADR-induced podocyte apoptosis was associated with the imbalance of p-Smad2/3, p-Smad1/5/8 the activity of caspase-3 and aberrant expressions of, Fas, FADD, Bax and Bcl-2. |
| 3 | 21073732 | Curcumin enhanced the phosphorylation of both p38MAPK and downstream HSP25; inhibited COX-2; induced a trend towards attenuation of F- to G-actin cleavage; and dramatically inhibited the activation of caspase-3 in vitro. |
| 4 | 21303966 | CRP exposure reduced caspase-3 enzyme activity and up-regulated the expression of the anti-apoptotic protein Bcl-2. |
| 5 | 21303966 | In the presence of the PI-3 kinase inhibitor LY294002, the ability of CRP to suppress caspase-3 activity was significantly reduced. |