Ignet

Gene Information

Gene symbol: CCL2

Gene name: chemokine (C-C motif) ligand 2

HGNC ID: 10618

Synonyms: MCP1, MCP-1, MCAF, SMC-CF, GDCF-2, HC11, MGC9434

Related Genes

#	Gene Symbol	Number of hits
1	ALB	1 hits
2	CCL19	1 hits
3	CCL21	1 hits
4	CCL5	1 hits
5	CCR2	1 hits
6	CNR2	1 hits
7	CXCL10	1 hits
8	HSPA5	1 hits
9	ICAM1	1 hits
10	IL6	1 hits
11	MAP3K14	1 hits
12	MAPK1	1 hits
13	NAMPT	1 hits
14	NFKB1	1 hits
15	NPHS1	1 hits
16	PDGFD	1 hits
17	SP1	1 hits
18	TAS2R13	1 hits
19	TLR4	1 hits
20	TNF	1 hits
21	TNFSF12	1 hits
22	VCAM1	1 hits

Related Sentences

#	PMID	Sentence
1	21866094	PDGF-A, -B, and both PDGF receptor chain mRNAs, fibronectin, type IV collagen, RANTES, MCP-1, and CCR-2 mRNAs were all increased in the renal cortex of PDGF-D transgenic mice.
2	16263740	PD98059, an inhibitor of ERK, partially prevented CML-induced MCP-1 gene expression.
3	16263740	Parthenolide and mithramycin A, inhibitors of NF-kappaB and Sp1, respectively, abolished CML-induced MCP-1 gene expression in a dose-dependent manner.
4	16263740	NF-kappaB and Sp1 regulate MCP-1 gene transcription.
5	17604001	We found that, in glomerular podocytes, induction of monocyte chemoattractant protein 1 (MCP-1) and inducible nitric oxide synthase (iNOS) by TNF-alpha was abrogated by K-7174.
6	17604001	Furthermore, K-7174-elicited UPR abrogated induction of MCP-1 and iNOS not only by TNF-alpha but also by medium conditioned by activated macrophages.
7	19420107	Glomerular podocytes in culture, verified to express the marker nephrin, were exposed to diabetic mediators such as high glucose or angiotensin II and assayed for MCP-1.
8	19420107	The TGF-beta-induced MCP-1 was found to activate the podocyte's cysteine-cysteine chemokine receptor 2 (CCR2) and, as a result, enhance the cellular motility, cause rearrangement of the actin cytoskeleton, and increase podocyte permeability to albumin in a Transwell assay.
9	19420107	The preceding effects of TGF-beta were replicated by treatment with recombinant MCP-1 and blocked by a neutralizing anti-MCP-1 antibody or a specific CCR2 inhibitor, RS102895.
10	19420107	In conclusion, this is the first description that TGF-beta signaling through PI3K induces the podocyte expression of MCP-1 that can then operate via CCR2 to increase cellular migration and alter albumin permeability characteristics.
11	20375985	Furthermore, visfatin induced tyrosine phosphorylation of the insulin receptor, activated downstream insulin signaling pathways such as Erk-1, Akt, and p38 MAPK, and markedly increased the levels of TGFbeta1, PAI-1, type I collagen, and MCP-1 in both renal cells.
12	20953353	TWEAK promotes the secretion of MCP-1 and RANTES through NF-kappaB RelA-containing complexes and upregulates CCl21 and CCL19 expression through NF-kappaB inducing kinase (NIK-) dependent RelB/NF-kappaB2 complexes.
13	20660016	Because TRB3 inhibits MCP-1, manipulation of TRB3 expression could provide a novel therapeutic approach in diabetic kidney disease.
14	18799549	We found that, in murine podocytes, expression of monocyte chemoattractant protein 1 (MCP-1) in response to TNF-alpha was suppressed by indomethacin but not by ibuprofen.
15	18799549	In tumor necrosis factor (TNF)-alpha-treated cells, suppression of MCP-1 by indomethacin was inversely correlated with induction of UPR, and other inducers of UPR including tunicamycin, thapsigargin, and A23187 reproduced the suppressive effect.
16	18799549	Subsequent experiments revealed that acute ablation of GRP78 protein by AB5 subtilase cytotoxin caused reinforcement of MCP-1 induction and NF-kappaB activation by TNF-alpha and that transfection with GRP78 significantly suppressed the cytokine-induced activation of NF-kappaB.
17	15918915	Gene expression of ICAM-1, VCAM-1 and RANTES was unaltered whereas Osteopontin and MCP-1 were induced by hypertension.
18	21703397	CCL2 blockade reduced glomerular leukocyte counts and renal-inducible nitric oxide synthase or IL-6 mRNA expression.
19	19887845	Knockdown of TLR2 and TLR4 inhibited the fibrinogen-induced MCP-1 mRNA upregulation.
20	16130407	IP-10 correlated IL-18, IL-6, TNF-alpha and MCP-1.
21	21810593	In addition, AM1241 reduced CCR2 expression in both renal cortex and cultured podocytes, suggesting that CB2 activation may interfere with the deleterious effects of MCP-1 signaling.