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Gene Information
Gene symbol: CLEC1B
Gene name: C-type lectin domain family 1, member B
HGNC ID: 24356
Synonyms: CLEC2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PDPN | 1 hits |
| 2 | SRC | 1 hits |
| 3 | SYK | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18215137 | The transmembrane protein podoplanin was identified on HEK-293T cells and was demonstrated to mediate both binding of HEK-293T cells to CLEC-2 and HEK-293T cell activation of CLEC-2-transfected DT-40 B-cells. |
| 2 | 18215137 | The present study identifies podoplanin as a ligand for CLEC-2 on renal cells. |
| 3 | 20345705 | In contrast, the C-type lectin receptor CLEC-2 mediates powerful platelet activation through Src and Syk kinases, but regulates Syk through a novel dimerization mechanism via a single YxxL motif known as a hemITAM. |
| 4 | 21781241 | The endogenous ligand of CLEC-2 has been identified as podoplanin, which is expressed on the surface of tumour cells and facilitates tumour metastasis by inducing platelet activation. |
| 5 | 21781241 | In the developmental stages, when the primary lymph sac is derived from the cardinal vein, podoplanin activates platelets in lymphatic endothelial cells by binding to CLEC-2, which facilitates blood/lymphatic vessel separation. |