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Gene Information
Gene symbol: CTGF
Gene name: connective tissue growth factor
HGNC ID: 2500
Synonyms: IGFBP8, CCN2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGT | 1 hits |
| 2 | HK2 | 1 hits |
| 3 | LRP1 | 1 hits |
| 4 | MAPK1 | 1 hits |
| 5 | MIRN192 | 1 hits |
| 6 | NTRK1 | 1 hits |
| 7 | SOSTDC1 | 1 hits |
| 8 | SYNPO | 1 hits |
| 9 | TGFB1 | 1 hits |
| 10 | TGFB2 | 1 hits |
| 11 | TSPYL2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15144593 | To assess the expression of connective tissue growth factor (CTGF), and the signaling pathway for the regulation of CTGF by transforming growth factor beta1 (TGF beta(1)) in podocytes. |
| 2 | 15144593 | In this study, we observed the effects of three potent profibrotic growth factors-TGF beta(1), Platelet-derived growth factor (PDGF), and Angiotensin II (AngII) on the expression of CTGF protein by Western blot analysis in cultured mouse podocytes, which is one of the most important cell construction of glomerular filter barrier, and we also investigated the underlying ERK and Smads signaling pathway through which TGF beta(1) regulates CTGF expression. |
| 3 | 19255250 | BMP signaling activity was visualized by phosphorylated Smad1, -5, and -8 (pSmad1/5/8) immunostaining, and related to expression of CTGF, SOSTDC1, and the podocyte differentiation markers WT1, synaptopodin, and nephrin. |
| 4 | 19255250 | In diabetic glomeruli, SOSTDC1 decreased in parallel with podocyte number, whereas CTGF was strongly increased. |
| 5 | 19657322 | Transforming growth factor-beta2 (TGF-beta2) stimulates the expression of pro-fibrotic connective tissue growth factor (CTGF) during the course of renal disease. |
| 6 | 19657322 | Because sphingosine kinase-1 (SK-1) activity is also upregulated by TGF-beta, we studied its effect on CTGF expression and on the development of renal fibrosis. |
| 7 | 20393144 | In contrast, CTGF increased miR-192/215 levels, causing a decrease in ZEB2, and consequently increased E-cadherin mRNA. |
| 8 | 20576680 | Connective tissue growth factor (CTGF) expression is stimulated by all TGF-beta isoforms and is abundant in glomerulosclerosis and other fibrotic disorders. |
| 9 | 20576680 | During the capillary loop and maturing glomerular stages and simultaneous with the presence of TGF-beta(1), -beta(2), and -beta(3) protein, CTGF mRNA expression was maximal and present only in differentiating glomerular epithelial cells. |
| 10 | 19214781 | CTGF is also able to interact with receptors on cells, including integrins, tyrosine receptor kinase A (TrkA), low density lipoprotein receptor-related protein (LRP) and heparan sulphate proteoglycans. |
| 11 | 20962744 | CDA1 small interfering RNA knockdown markedly attenuated, whereas its overexpression increased TGF-? signaling, modulating the expression of TGF-?, TGF-? receptors, connective tissue growth factor, collagen types I, III, IV, and fibronectin genes in HK-2 cells. |