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Gene Information
Gene symbol: EDN1
Gene name: endothelin 1
HGNC ID: 3176
Synonyms: ET1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ACE | 1 hits |
| 2 | ALB | 1 hits |
| 3 | AR | 1 hits |
| 4 | EDNRA | 1 hits |
| 5 | EDNRB | 1 hits |
| 6 | NPHS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16449275 | It was the purpose of the present study to analyse by immunohistology the expression of ET-1 as well as of the two ET receptors (ET-RA and ET-RB) in the different cells and compartments of kidney grafts and control kidneys. |
| 2 | 18287402 | Indeed, ET-1 was synthesized and released from glomerular endothelial cells when incubated with PE sera, and recombinant ET-1 triggered nephrin shedding from podocytes. |
| 3 | 18287402 | Moreover, VEGF blockade induced ET-1 release from endothelial cells, and in turn the conditioned medium obtained triggered nephrin loss. |
| 4 | 18648345 | There is strong evidence that endothelin-1, a peptide with growth-promoting and vasoconstricting properties, has a central role in the pathogenesis of proteinuria and glomerulosclerosis, which is mediated via activation of the ET(A) receptor. |
| 5 | 18648345 | Several antiproteinuric drugs, including angiotensin-converting-enzyme inhibitors, angiotensin receptor antagonists, statins and certain calcium channel blockers, inhibit the formation of endothelin-1. |
| 6 | 21893994 | Because podocytes are cells in the glomerulus that form a crucial component of the glomerular filtration barrier, contributing to size selectivity and maintaining a large filtration surface, we focus on evidence that suggest ET-1 may promote podocyte injury thereby aggravating albumin urinary loss and alteration of the glomerular microvasculature. |