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Gene Information
Gene symbol: EGFR
Gene name: epidermal growth factor receptor
HGNC ID: 3236
Synonyms: ERBB1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADAM17 | 1 hits |
| 2 | AGT | 1 hits |
| 3 | BDKRB2 | 1 hits |
| 4 | EGF | 1 hits |
| 5 | EREG | 1 hits |
| 6 | JAK2 | 1 hits |
| 7 | MAPK1 | 1 hits |
| 8 | SLC9A1 | 1 hits |
| 9 | TGFA | 1 hits |
| 10 | TJP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19341767 | The EGFR kinase inhibitor, AG1478, blocked activation of NHE-1, but did not block EGF-induced phosphorylation of Jak2 or CaM. |
| 2 | 19341767 | These results suggest that EGF induces NHE-1 activity in podocytes through two pathways: (1) EGF-->EGFR-->Jak2 activation (independent of EGFR tyrosine kinase activity)-->tyrosine phosphorylation of CaM-->CaM binding to NHE-1-->conformational change of NHE-1-->activation of NHE-1; and (2) EGF-->EGFR-->EGFR kinase activation-->association of CaM with NHE-1 (independent of Jak2)-->conformational change of NHE-1-->activation of NHE-1. |
| 3 | 20566668 | We show that BK2 receptor (BK2R) stimulation transactivates the epidermal growth factor receptor (EGFR). |
| 4 | 20566668 | EGFR transactivation is mediated by a disintegrin and metalloenzyme (ADAM) family members, which are required for both extracellular signal-regulated kinase (ERK) and EGFR activation by BK. |
| 5 | 20566668 | Using a gene-silencing approach we observed that both BK-induced ERK activation and BK-induced permeability decrease in podocytes is attenuated by ADAM17 down-regulation, and we identified epiregulin (ER) as the EGFR ligand participating in ADAM-dependent BK2R-EGFR cross-talk. |
| 6 | 20566668 | We propose that ZO-1 redistribution is an important element of BK-induced permeability change and the signaling events involved in ZO-1 rearrangement include transactivation of the EGFR via ADAM17 activation and ER shedding. |
| 7 | 19535569 | A disintegrin and metalloproteinase (ADAM)17 sheds growth factors from the cell membrane, including epidermal growth factor receptor (EGFR) ligand transforming growth factor (TGF)-alpha. |
| 8 | 19535569 | In mice, angiotensin II infusion induces renal fibrosis via ADAM17-mediated TGF-alpha shedding and subsequent EGFR activation. |