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Gene Information
Gene symbol: HIF1A
Gene name: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HGNC ID: 4910
Synonyms: MOP1, HIF-1alpha, PASD8, HIF1, bHLHe78
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ARNT | 1 hits |
| 2 | CXCR4 | 1 hits |
| 3 | EPAS1 | 1 hits |
| 4 | JUND | 1 hits |
| 5 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12660327 | In response to hypoxia, stabilized HIF-1alpha and HIF-2alpha proteins bind HIF-1beta and initiate expression of genes that alleviate hypoxic stress, including those promoting neovascularization. |
| 2 | 12660327 | Both HIF-1 and HIF-2 heterodimers were identified in newborn kidney lysates by immunoprecipitation with HIF-1alpha, HIF-2alpha, and HIF-1beta antibodies and Western blots. |
| 3 | 16374431 | The HIF-target gene VEGF colocalized with HIF-1alpha protein in glomeruli and medullary collecting ducts. |
| 4 | 20019191 | This CXCR4 positivity was associated with nuclear localization of HIF1alpha only in podocytes of NSC, indicating transcriptional activity of HIF. |
| 5 | 21640331 | Accordingly, small-interfering RNA-mediated JUND knockdown in conditionally immortalized human podocyte cell lines led to increased VEGFA and HIF1A expression. |