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Gene Information
Gene symbol: HSPA5
Gene name: heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HGNC ID: 5238
Synonyms: BiP
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALB | 1 hits |
| 2 | CCL2 | 1 hits |
| 3 | HSP90B1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19640905 | In the present study, we show that alpha-actinin-4 K256E upregulates grp94 and CHOP expression in COS cells and significantly exacerbates induction of bip and CHOP in GEC in the presence of tunicamycin. |
| 2 | 18799549 | Subsequent experiments revealed that acute ablation of GRP78 protein by AB5 subtilase cytotoxin caused reinforcement of MCP-1 induction and NF-kappaB activation by TNF-alpha and that transfection with GRP78 significantly suppressed the cytokine-induced activation of NF-kappaB. |
| 3 | 21679752 | Accumulation of albumin in podocytes induced ER stress and apoptosis in a concentration-dependent manner as indicated by upregulation of GRP78 and caspase-12. |
| 4 | 21959089 | Moreover, albumin overload induced expression of the endoplasmic reticulum (ER) stress protein GRP78, led to caspase-12 activation and ultimately podocyte apoptosis, all of which were abolished by the knockdown of TRPC6 using TRPC6 siRNA. |