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Gene Information
Gene symbol: INS
Gene name: insulin
HGNC ID: 6081
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | AGT | 1 hits |
| 3 | AKT1 | 1 hits |
| 4 | CD2AP | 1 hits |
| 5 | DUOX1 | 1 hits |
| 6 | INPPL1 | 1 hits |
| 7 | NPHS1 | 1 hits |
| 8 | NR3C2 | 1 hits |
| 9 | RETN | 1 hits |
| 10 | SLC2A8 | 1 hits |
| 11 | SREBF1 | 1 hits |
| 12 | SREBF2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15741607 | Additionally, GLUT8 expression was studied using two different models of insulin resistance, GLUT4-/- and db/db mice. |
| 2 | 19261739 | Recent evidence suggests that mineralocorticoid receptor (MR) antagonism has beneficial effects on tissue oxidative stress and insulin metabolic signaling as well as reducing proteinuria. |
| 3 | 20654688 | To study the role of CD2-associated protein (CD2AP) in podocyte injury, we performed a yeast two-hybrid screening on a glomerular library, and found that CD2AP bound to SH2-domain-containing inositol polyphosphate 5-phosphatase 2 (SHIP2), a negative regulator of insulin signalling. |
| 4 | 20654688 | Overexpression of SHIP2 in cultured podocytes reduces Akt activation in response to insulin, and promotes apoptosis. |
| 5 | 20654688 | These results indicate that SHIP2 downregulates insulin signalling in podocytes. |
| 6 | 21177830 | The vasodilator ?-blocker nebivolol reduces nicotinamide adenine dinucleotide phosphate oxidase activity, increases bioavailable nitric oxide, and improves insulin sensitivity. |
| 7 | 21177830 | Compared with Zucker lean, ZO controls exhibited increased proteinuria and ?-glutamyl transpeptidase, reductions in systemic insulin sensitivity in association with increased renal renin, (pro)renin receptor, angiotensin II type 1 receptor, and mineralocorticoid receptor immunostaining, oxidative stress, and glomerular tubular structural abnormalities that were substantially improved with in vivo nebivolol treatment. |
| 8 | 21209008 | Diet-induced obesity (DIO) and insulin resistance in mice are associated with proteinuria, renal mesangial expansion, accumulation of extracellular matrix proteins, and activation of oxidative stress, proinflammatory cytokines, profibrotic growth factors, and the sterol regulatory element binding proteins, SREBP-1 and SREBP-2, that mediate increases in fatty acid and cholesterol synthesis. |
| 9 | 19833886 | Actin stabilization prevented nephrin trafficking as well as nephrin-positive effect on insulin release. |
| 10 | 21660954 | High glucose treatment also abolished the stimulatory effects of insulin on BK(Ca) current density, although insulin continued to increase phosphorylation of Erk and Akt under those conditions. |
| 11 | 21694920 | Adiponectin potentiates insulin in its post-receptor signaling resulting in glucose oxidation in mitochondria. |
| 12 | 21694920 | Fatty acid accumulation and resistin inhibit insulin and adiponectin. |