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Gene Information
Gene symbol: KCNMA1
Gene name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
HGNC ID: 6284
Synonyms: KCa1.1, mSLO1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GSTA1 | 1 hits |
| 2 | KIRREL | 1 hits |
| 3 | MAGI1 | 1 hits |
| 4 | NPHS1 | 1 hits |
| 5 | TRPC3 | 1 hits |
| 6 | TRPC6 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19052171 | In podocytes, small interfering RNA knockdown of endogenous TRPC6 reduced steady-state surface expression of endogenous Slo1 channels, but knockdown of TRPC3 had no effect. |
| 2 | 19052171 | These data indicate that TRPC6 and TRPC3 channels can bind to Slo1, and this colocalization may allow them to serve as a source of Ca(2+) for the activation of BK(Ca) channels. |
| 3 | 19403801 | Partial knockdown of endogenous MAGI-1 expression by small interfering RNA (siRNA) in differentiated podocytes increased the surface expression of endogenous Slo1 as assessed by electrophysiology and cell-surface biotinylation assays, whereas overexpression of MAGI-1a reduced steady-state voltage-evoked outward current through podocyte BK(Ca) channels. |
| 4 | 19794150 | Here we show that Slo1 proteins interact with Neph1, a member of the immunoglobulin superfamily expressed in slit diaphragm domains of podocytes and in vertebrate and invertebrate nervous systems. |
| 5 | 19794150 | Neph1 can interact with all three extreme COOH-terminal variants of Slo1 (Slo1(VEDEC), Slo1(QEERL), and Slo1(EMVYR)) as ascertained by glutathione S-transferase (GST) pull-down assays and by coimmunoprecipitation. |
| 6 | 19794150 | Neph1 is partially colocalized in intracellular compartments with endogenous Slo1 in podocytes and ciliary ganglion neurons. |
| 7 | 19794150 | Consistent with this, small interfering RNA (siRNA) knockdown of endogenous Neph1 in embryonic day 10 ciliary ganglion neurons causes an increase in steady-state surface expression of Slo1 and an increase in whole cell Ca(2+)-dependent K(+) current. |
| 8 | 19794150 | Surprisingly, a comparable Neph1 knockdown in podocytes causes a decrease in surface expression of Slo1 and a decrease in whole cell BK(Ca) currents. |
| 9 | 18480178 | We detected nephrin binding to the Slo1 VEDEC splice variant, which is typically retained in intracellular stores, and to the beta4-subunit. |
| 10 | 18480178 | Stimulation of Slo1 VEDEC surface expression in HEK-293T cells was also observed by coexpressing a small construct encoding only the distal COOH-terminal domains of nephrin that interact with Slo1. |
| 11 | 18480178 | Reduction of endogenous nephrin expression by application of small interfering RNA to differentiated cells of an immortalized podocyte cell line markedly reduced the steady-state surface expression of Slo1 as assessed by electrophysiology and cell-surface biotinylation assays. |