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Gene Information
Gene symbol: RARA
Gene name: retinoic acid receptor, alpha
HGNC ID: 9864
Synonyms: RAR, NR1B1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | NFKB1 | 1 hits |
| 2 | NPHS1 | 1 hits |
| 3 | RXRG | 1 hits |
| 4 | TNF | 1 hits |
| 5 | VDR | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19474283 | In this report, we investigated roles of the retinoic acid receptor (RAR), the retinoid X receptor (RXR) and the vitamin D receptor (VDR) in the regulation of the nephrin gene. |
| 2 | 19474283 | Reporter podocytes were treated with agonists and/or antagonists of RAR, RXR or VDR, and activities of the nephrin gene promoter, the retinoic acid response element (RARE) and the vitamin D response element (VDRE) were evaluated. |
| 3 | 19474283 | The nephrin gene promoter was also activated by these agents, which was mediated by RAR and VDR, but unexpectedly, not by RXR. |
| 4 | 19474283 | ATRA-triggered, RAR-mediated activation of the nephrin gene promoter was not suppressed by the VDR antagonist. |
| 5 | 19474283 | In contrast, the 1,25(OH)(2)D(3)-triggered, VDR-mediated activation of the nephrin gene promoter was significantly suppressed by the RAR antagonist, but not by RXR antagonists. |
| 6 | 20237236 | In the present investigation, we identified that TNF-alpha selectively represses activity of RAR but not VDR. |
| 7 | 20237236 | TNF-alpha caused activation of NF-kappaB, MAP kinases, and PI3K-Akt in podocytes, whereas blockade of these molecules did not affect inhibition of RAR by TNF-alpha. |
| 8 | 17182884 | Podocytes expressed most isoforms of retinoic acid receptors (RAR) and retinoid X receptors (RXR) with the exception of RXRgamma. |