Ignet

Gene Information

Gene symbol: TNF

Gene name: tumor necrosis factor

HGNC ID: 11892

Synonyms: TNFSF2, DIF, TNF-alpha

Related Genes

#	Gene Symbol	Number of hits
1	ANGPT2	1 hits
2	CCL2	1 hits
3	CD40	1 hits
4	CXCL10	1 hits
5	FAS	1 hits
6	GORASP1	1 hits
7	MAPK1	1 hits
8	MAPK14	1 hits
9	NFKB1	1 hits
10	NOS2A	1 hits
11	NPHS1	1 hits
12	RARA	1 hits
13	TNFRSF11B	1 hits
14	TNFSF10	1 hits
15	TNFSF12	1 hits
16	TRAF2	1 hits
17	VDR	1 hits

Related Sentences

#	PMID	Sentence
1	16288986	Neither IL-1beta nor TNFalpha alone has an effect on nephrin promoter activity suggesting that additional posttranscriptional regulatory events might be operative.
2	16288986	In the presence of PPARalpha agonists, IL-1beta or TNFalpha, the decay of nephrin mRNA was drastically reduced thus arguing for an additional posttranscriptional mode of action.
3	16205945	The expression of NF-kappaB subunits p65 and p50, and the NF-kappaB regulated proinflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6) and intercellular adhesion molecule-1 (ICAM-1) as well as CD68 and synaptopodin was examined by Southwestern histochemistry (SWH) or immunohistochemistry.
4	16514436	Furthermore, TNFalpha and IL-18 phosphorylated neutrophil p38 mitogen-activated protein kinase (MAPK), but IL-18-mediated p38 MAPK phosphorylation was unaffected by anti-TNFalpha antibody.
5	16626513	Increased TNF-alpha in plasma and glomeruli may upregulate Ang2 expression in glomeruli.
6	17604001	We found that, in glomerular podocytes, induction of monocyte chemoattractant protein 1 (MCP-1) and inducible nitric oxide synthase (iNOS) by TNF-alpha was abrogated by K-7174.
7	17604001	Furthermore, K-7174-elicited UPR abrogated induction of MCP-1 and iNOS not only by TNF-alpha but also by medium conditioned by activated macrophages.
8	19240767	TNF-related apoptosisinducing ligand (TRAIL) and osteoprotegerin had the highest level of expression.
9	20953353	Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury.
10	20953353	TNF-related apoptosis-inducing ligand (TRAIL and its potential decoy receptor osteoprotegerin are the two most upregulated death-related genes in human diabetic nephropathy.
11	20953353	While TNF only activates canonical NF-kappaB signaling, TWEAK promotes both canonical and noncanonical NF-kappaB activation in tubular cells, regulating different inflammatory responses.
12	18799549	We found that, in murine podocytes, expression of monocyte chemoattractant protein 1 (MCP-1) in response to TNF-alpha was suppressed by indomethacin but not by ibuprofen.
13	18799549	In tumor necrosis factor (TNF)-alpha-treated cells, suppression of MCP-1 by indomethacin was inversely correlated with induction of UPR, and other inducers of UPR including tunicamycin, thapsigargin, and A23187 reproduced the suppressive effect.
14	18799549	Reporter assays showed that indomethacin as well as thapsigargin attenuated activation of NF-kappaB by TNF-alpha, and it was associated with enhanced degradation of TNF receptor-associated factor 2 (TRAF2) and blunted degradation of IkappaBbeta.
15	20237236	We previously reported that 1) expression of nephrin in cultured podocytes is reinforced by retinoic acid (RA) and 1,25-dihydroxyvitamin D(3), 2) these effects are mediated by retinoic acid receptor (RAR) and vitamin D receptor (VDR), and 3) basal and inducible expression of nephrin is downregulated by TNF-alpha.
16	20237236	In the present investigation, we identified that TNF-alpha selectively represses activity of RAR but not VDR.
17	20237236	To elucidate mechanisms underlying this observation, we tested involvement of downstream targets for TNF-alpha: nuclear factor-kappaB (NF-kappaB), mitogen-activated protein (MAP) kinases, phosphatidylinositol 3-kinase (PI3K)-Akt, and cAMP-protein kinase A (PKA).
18	20237236	TNF-alpha caused activation of NF-kappaB, MAP kinases, and PI3K-Akt in podocytes, whereas blockade of these molecules did not affect inhibition of RAR by TNF-alpha.
19	16130407	IP-10 correlated IL-18, IL-6, TNF-alpha and MCP-1.