Ignet

Gene Information

Gene symbol: WT1

Gene name: Wilms tumor 1

HGNC ID: 12796

Synonyms: WAGR, WIT-2, AWT1

Related Genes

#	Gene Symbol	Number of hits
1	ALB	1 hits
2	CD79B	1 hits
3	CXXC5	1 hits
4	DES	1 hits
5	FGF2	1 hits
6	HGF	1 hits
7	LIMS1	1 hits
8	NES	1 hits
9	NOV	1 hits
10	NPHS1	1 hits
11	NPHS2	1 hits
12	NUDT6	1 hits
13	SULF1	1 hits
14	SULF2	1 hits
15	SYNPO	1 hits
16	TGFB1	1 hits
17	VEGFA	1 hits

Related Sentences

#	PMID	Sentence
1	9626060	Insofar as novH has been shown to be a target for WT1 regulation, novH might play an important role during normal nephrogenesis and in the development of Wilms' tumors.
2	9626060	In general, the highest novH expression was noted in the Wilms' tumor, genitourinary anomalies, aniridia, and mental retardation (WAGR)-associated Wilms' tumors.
3	9626060	In addition, absence or very low levels of WT1 are correlated with higher novH expression, and its variable expression in cases with mutant WT1 (sporadic and DDS) suggests that the potential activation and repression transcriptional functions possessed by WT1 are likely dependent on the specific mutation incurred.
4	14507316	Podocytes in IGB expressed WT1, synaptopodin, podocalyxin, and nephrin, and their expression was stronger in MGB.
5	16614054	Nestin was significantly upregulated in a cell line with inducible Wt1 expression upon induction of Wt1.
6	17457373	In the puromycin and the combined models, changes in GLEPP1 expression were corticosteroid-sensitive, whereas B7.1, WT1, vascular endothelial growth factor, and most slit diaphragm genes involved later in the combined model, except podocin, were corticosteroid-resistant.
7	17596726	Urinary nephrin and synaptopodin expressions are correlated with baseline clinical parameters such as proteinuria or renal function, while WT-1 expression is related to the degree of histological damage.
8	20375988	When HGF was expressed ectopically in vivo, it ameliorated adriamycin-induced albuminuria, preserved WT1 and nephrin expression, and inhibited podocyte apoptosis.
9	21390327	Co-immunoprecipitation and pull-down experiments revealed that PINCH1 interacted with Wilms tumor 1 protein (WT1), a nuclear transcription factor that is essential for regulating podocyte-specific gene expression in adult kidney.
10	21289599	Further, both agonists restored WT-1 staining along with podocin and nephrin mRNA expression, suggesting podocyte protection.
11	20220130	In this study, we identified a gene, CXXC5, which we have renamed WID (WT1-induced Inhibitor of Dishevelled), as a novel WT1 transcriptional target that negatively regulates WNT/beta-catenin signaling.
12	21719793	Here, we found that the transcription factor Wilms' Tumor 1 (WT1) modulates VEGFA and FGF2 signaling by increasing the expression of the 6-O-endosulfatases Sulf1 and Sulf2, which remodel the heparan sulfate 6-O-sulfation pattern in the extracellular matrix.
13	21220752	Immunostaining for Wilms' tumor-1 (WT1) and synaptopodin, markers of podocytes, was attenuated, whereas immunostaining for desmin, a marker of podocyte damage, and 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress, was up-regulated in the glomeruli of diabetic rats.
14	21378152	We aimed to address whether TGF-beta affects WT1 expression in podocytes.
15	21378152	A human podocyte cell line treated with TGF-beta1 and kidneys in Alb/TGF-beta1-transgenic mice were analyzed for WT1 expression.
16	21378152	In cultured podocytes, TGF-beta1 reduced WT1 protein expression determined by western blotting beginning at 8 h and decreased WT1 messenger RNA (mRNA) expression measured by quantitative reverse transcription-polymerase chain reaction beginning at 3 h.
17	21378152	TGF-beta1 did not alter luciferase activity of the reporter construct for a human WT1 promoter but reduced that for a human WT1 5' enhancer construct, suggesting that TGF-beta1 may regulate WT1 expression by altering the 5' enhancer activity.
18	21378152	TGF-beta1 reduces WT1 expression in cultured human podocytes and podocytes in mice before overt glomerulosclerosis begins.
19	21775482	Exogenous expression of HGF produced evidently beneficial effects, leading to restoration of Wilms' tumor-1 (WT1) and ?-actinin-4 expression and attenuation of ultrastructural damage of the podocytes.
20	21775482	In vitro, HGF not only restored WT1 and ?-actinin-4 expression but also inhibited albumin leakage of podocytes incubated with PAN in a Transwell culture chamber.