Ignet

Gene Pair: IL15, IFNG

Related Sentences

#	PMID	Sentence
1	10811870	Type I IFN induced IL-15 production and strongly promoted a T helper cell type 1 response.
2	11265774	While PC upregulated expression of major histocompatibility complex class I/II and costimulatory molecules on the surface of DC, CD40L +/- IFN-gamma increased interleukin (IL)- 12 and to a lesser extent, IL-15 production by DC.
3	16388819	Cytokines IL-2 and IL-12/IL-15 induced perforin release coupled with an IFN-gamma type-1 response.
4	16619285	The expression of antigen-specific effector functions, such as the production of interferon-gamma and cytotoxicity, were impaired in CD8+ T cells, but not CD4+ T cells, from IL-15-deficient mice.
5	18462848	Interestingly, intranasal delivery of the IL-15 construct with pcD-VP1 significantly enhanced the cell-mediated immunity (CMI) compared to the pcD-VP1 alone, as evidenced by the higher level of antigen-specific T-cell proliferation, cytotoxic T lymphocyte (CTL) response and higher expressions of IFN-gamma in both CD4+ and CD8+ T cells inform the spleen and mucosal sites.
6	21307131	However, further studies indicated that IFN I alone was not sufficient to activate NK cells, especially in the presence of a tumor, and DC-derived IL-15 was additionally required for tumoricidal NK activation.
7	21307131	These results suggest that induction of IFN I by VSV-?M51 allows DCs to overcome tumor-associated immunosuppression and facilitate IL-15-mediated priming of tumoricidal NK cells.