Ignet

Gene Pair: MAPK8, NOS2A

Related Sentences

#	PMID	Sentence
1	21450974	Using a selective inhibitor of JNK (SP600125) and JNK1/2 small interfering RNA (siRNA) knocked-down macrophages, it was observed that PGN-induced iNOS and NO expression is significantly inhibited.
2	21450974	This suggested that JNK MAPK plays an essential role in PGN-induced iNOS expression and NO production.
3	21450974	These results indicate that the JNK MAPK positively regulate PGN-induced iNOS and NO expression by activating NF-?B and AP-1 transcription factors, whereas the ERK pathway plays a negative regulatory role via affecting NF-?B activity.