Ignet

Gene Pair: ADIPOQ, APPL1

Related Sentences

#	PMID	Sentence
1	17287464	Suppression of APPL1 expression by RNA interference significantly attenuated adiponectin-induced phosphorylation of AMP-activated protein kinase (AMPK) at Thr(172) and eNOS at Ser(1177), and the complex formation between eNOS and heat shock protein 90, resulting in a marked reduction of NO production.
2	21151013	Alterations in the expression of APPL1 may be involved in the observed insensitivity to adiponectin in ZDF rats.
3	16814726	A recent paper (Mao et al., 2006) shows that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and mediates some of adiponectin's actions, identifying a novel mechanism linking adiponectin to insulin sensitization.