Ignet

Gene Pair Information

Gene Pair: APLN, INS

Related Sentences

#	PMID	Sentence
1	18484561	To investigate blood apelin concentrations in patients with newly diagnosed and untreated type 2 diabetes mellitus (T2DM) who had no additional disorder and to investigate the association of apelin with adiponectin, body mass indexes (BMI) and insulin sensitivity.
2	19940327	Adipose tissue produces multiple cytokines(TNF-alpha, IL-6, PAI-1, CRP, angiotensinogen, leptin, adiponectin, visfatin, apelin, resistin)which decrease insulin sensitivity and induce inflammatory processes, endothelial dysfunction,and atherosclerosis.
3	19861585	The recently discovered peptide apelin is known to be involved in the maintenance of insulin sensitivity.
4	19861585	Fasting glucose, insulin, and adiponectin levels were determined on mice with generalized deficiency of apelin (APKO).
5	21264801	Furthermore we examined the association of apelin serum levels with insulin sensitivity/resistance and body fat distribution as probably dependent cardiovascular risk factors.
6	21264801	Furthermore, neither parameters of insulin sensitivity like insulin sensitivity index (ISI), nor fat distribution like BMI, grade of adiposity, total adipose tissue or VAT were associated with apelin serum levels.
7	20233941	Apelin, an adipocyte-secreted factor upregulated by insulin, is increased in adipose tissue (AT) and plasma with obesity.
8	20233941	However, the regulation of apelin and APJ (apelin receptor) expression in skeletal muscle in relation to insulin resistance or type 2 diabetes is not known.
9	21395477	Apelin and its receptor have emerged as promising targets for the treatment of insulin resistance.
10	21395477	Indeed, peripheral administration of apelin stimulates glucose utilization and insulin sensitivity via a nitric oxide (NO) pathway.