Ignet

Gene Pair: FOXO1, MTTP

Related Sentences

#	PMID	Sentence
1	18497885	To characterize the underlying mechanism, we studied hepatic MTP regulation by forkhead box O1 (FoxO1), a transcription factor that plays a key role in hepatic insulin signaling.
2	18497885	In HepG2 cells, MTP expression was induced by FoxO1 and inhibited by exposure to insulin.
3	18497885	This effect correlated with the ability of FoxO1 to bind and stimulate MTP promoter activity.
4	18497885	We generated mice that expressed a constitutively active FoxO1 transgene and found that increased FoxO1 activity was associated with enhanced MTP expression, augmented VLDL production, and elevated plasma triglyceride levels.
5	18497885	In contrast, RNAi-mediated silencing of hepatic FoxO1 was associated with reduced MTP and VLDL production in adult mice.