Ignet

Gene Pair Information

Gene Pair: GHR, INS

Related Sentences

#	PMID	Sentence
1	3542649	This result provides direct confirmation that insulin is not associated with a circulating serum binding protein(s) and that insulin is present predominantly as a monomer in plasma.
2	3053958	Insulin can regulate IGF-I production, acting on the GH receptor or at a post-receptor site.
3	8281728	GHBP, expressed as a percentage of (125I)GH bound, was determined in 33 patients with Type 1 diabetes (M/F = 19/14, 12.3 +/- 0.4 years) before (day 0), after 5 days (day 5) and after 3 months (month 3) of insulin therapy.
4	8281728	Thus, (1) circulating GHBP is low in newly diagnosed patients with Type 1 diabetes, and increases after 3 months of insulin therapy but does not normalize and (2) the severity of biochemical derangement and residual beta-cell function at diagnosis may determine GHBP status and its recovery.
5	7536205	Improvement in glycemic control, as determined by a change in hemoglobin-A1c, correlated positively with improvement in IGF-I, IGF-II, IGFBP-3, GHBP, and weight gain after 1 month of insulin therapy.
6	14510911	Insulin and leptin were significantly associated with GHBP, both in women (r=0.48, P<0.001 and r=0.43, P=0.001, respectively) and in men (r=0.40, P=0.01 and r=0.34, P=0.03, respectively).
7	15921943	Neither total nor weight adjusted insulin requirements correlated to total PGH, calculated free PGH, nor GHBP.
8	18431372	Pegvisomant, a recombinant growth-hormone-receptor antagonist, suppresses production of insulin-like growth factor I.
9	21555853	Here we have employed a rat insulin II promoter-driven (RIP-driven) Cre recombinase to disrupt the GH receptor in ? cells (?GHRKO). ?GHRKO mice fed a standard chow diet exhibited impaired glucose-stimulated insulin secretion but had no changes in ? cell mass.