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PMID |
Sentence |
1 |
8036284
|
GIP at a dose of 1, 2 or 4 pmol/kg/min augmented the 90-120 min insulin response by 69, 841 and 920 pmol/l, while GLP-1(7-37), at a dose of 1.5 pmol/kg/min augmented the insulin response by 2106 pmol/l.
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2 |
8036284
|
In the diabetic subjects, GIP had no effect, while GLP-1(7-37) augmented the insulin response by 929 pmol/l.
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3 |
18593849
|
GIP is produced by dispersed enteroendocrine cells and interestingly at times is coexpressed with GLP-1.
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4 |
20519806
|
alpha-glucosidase inhibitors (alphaGIs) increase active glucagon-like peptide-1 (GLP-1) and reduce the total glucosedependent insulinotropic polypeptide (GIP) levels, but their ability to prevent diabetes remains uncertain.
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5 |
21047927
|
This disruption of glucose homeostasis had no impact on postprandial GLP-1 responses (AUC, 1.5 ± 0.7 vs. 2.0 ± 0.5 nm · 4 h; P = 0.56), but resulted in exaggerated postprandial GIP (6.2 ± 1.0 vs. 10.0 ± 1.3 nm · 4 h; P = 0.003) and glucagon responses (1.6 ± 1.5 vs. 2.4 ± 3.2; P = 0.007).
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6 |
21330636
|
We studied whether GIP can alter the insulinotropic or glucagonostatic activity of GLP-1 in type 2 diabetic patients.
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7 |
21330636
|
Rather, the suppression of glucagon elicited by GLP-1 was antagonized by the addition of GIP (P = 0.008).
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8 |
21330636
|
FFA were suppressed by GLP-1 (P < 0.0001) and hardly affected by GIP (P = 0.07).
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9 |
21595261
|
While glucagon secretion is stimulated by GIP, GLP-1 suppresses glucagon secretion.
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10 |
21595269
|
Gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide(GIP) and glucagon-like peptide-1 (GLP-1) are incretin hormones released upon meal ingestion, and GIP and/or GLP-1 signaling is decreased in diabetic state.
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