Ignet

Gene Pair: IDE, APLP2

Related Sentences

#	PMID	Sentence
1	12941771	IDE inhibition by bacitracin impaired amylin degradation, increased amyloid formation, and increased amylin-induced cytotoxicity, suggesting a role for IDE in amylin clearance and the prevention of amylin aggregation.
2	15850385	Deletion of insulin-degrading enzyme (IDE) in mice causes accumulation of cerebral amyloid beta-protein (Abeta), hyperinsulinemia, and glucose intolerance.
3	16574064	Insulin degrading enzyme (IDE), a zinc metalloprotease, can specifically recognize and degrade insulin, as well as several amyloidogenic peptides such as amyloid beta (Abeta) and amylin.
4	21448434	Insulin-degrading enzyme (IDE) is a thiol sensitive peptidase that degrades insulin and amyloid ?, and has been linked to type 2 diabetes mellitus and Alzheimer's disease.