# |
PMID |
Sentence |
1 |
21914779
|
Infection increased macrophage chemoattractant protein-1, visfatin, and IL-6 secretion, whereas resistin and adiponectin were decreased.
|
2 |
12660878
|
Circulating IL-6 and leptin levels showed a positive association with BMI (r = 0.24, p = 0.04 and r = 0.70, p < 0.0001), whereas adiponectin was not correlated to BMI.
|
3 |
12663465
|
Furthermore, the inverse correlation between plasma levels of hs-CRP and plasma adiponectin remained significant despite correction for obesity-associated variables (partial r = -0.32, P < 0.05), whereas the inverse correlation between adiponectin plasma levels or adiponectin gene expression in adipose tissue with plasma IL-6 were largely dependent on the clustering of obesity-associated variables.
|
4 |
12663465
|
In conclusion, our data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk.
|
5 |
12684358
|
Body mass index decreased more in the intervention group than in controls (-4.2; P<.001), as did serum concentrations of IL-6 (-1.1 pg/mL; P =.009), IL-18 (-57 pg/mL; P =.02), and CRP (-1.6 mg/L; P =.008), while adiponectin levels increased significantly (2.2 microg/mL; P =.01).
|
6 |
12829646
|
Adiponectin expression was not related to plasma levels of leptin or interleukin-6.
|
7 |
12927809
|
Several observations showed that the adiponectin and aP2 genes can be differentially regulated in adipocytes: (1) Topiramate, an anti-epileptic agent with weight-reducing properties, increased adiponectin mRNA levels and secretion, but did not, like the thiazolidinediones, increase aP2 expression; (2) IL-6 reduced adiponectin, but significantly increased, aP2 expression; and (3) TNFalpha inhibited adiponectin, but paradoxically increased, aP2 expression in PPAR gamma 2-infected C/EBP alpha null cells.
|
8 |
14749206
|
Twenty-four-week treatment with rosiglitazone (8 mg/day) compared with placebo significantly increased the expression of adiponectin, peroxisome proliferator-activated receptor-gamma (PPARgamma), and PPARgamma coactivator 1 and decreased IL-6 expression.
|
9 |
16734148
|
Adiponectin correlated negatively with CRP, IL-6 and ET-1, BMI and HbA1c, whereas inflammatory and vascular markers correlated positively with each other and with BMI and HbA1c.
|
10 |
16423635
|
Serum IL-6 concentration was negatively correlated to high-density lipoprotein cholesterol (r = -0.295, P = .004), but was not associated with HOMA-IR (r = 0.016, P = .871), body mass index (BMI) (r = 0.090, P = .375), systolic (r = 0.169, P = .116) and diastolic (r = -0.061, P = .570) blood pressures, leptin (r = 0.062, P = .544), and adiponectin (r = -0.020, P = .841) in these patients.
|
11 |
16814613
|
Adiponectin levels increased from 3.7 to 10.3 mug/mL at week 48 (P < .01); the levels of the other cytokines were unchanged: TNF-alpha, 9.1 vs 8.8 pg/mL; IL-1a, 3.9 vs 3.4 pg/mL; IL-6, 19.4 vs 13.4 pg/mL; and leptin, 24.8 vs 29.6 ng/mL (P > .05 for all).
|
12 |
16868887
|
Reduction of hyperglycaemia results in decreased sE-selectin, A1GP, sICAM-1 and IL6, while other inflammatory factors including CRP, SAA and adiponectin are not affected.
|
13 |
17505154
|
TNF-alpha, IL-6 and hs-CRP levels were positively, adiponectin negatively correlated with adipocyte size.
|
14 |
17264850
|
After adjustment for these factors, adiponectin was significantly inversely associated with insulin resistance, triglyceride, C-reactive protein (but not interleukin 6), tissue plasminogen activator and alanine aminotransferase and positively associated with high-density lipoprotein cholesterol (HDL-cholesterol) and Factor VIII, factors associated with diabetes.
|
15 |
18334666
|
In summary, this study demonstrates that the antiobesity effect of HO-1 induction results in an increase in adiponectin secretion, in vivo and in vitro, a decrease in TNF-alpha and IL-6, and a reduction in weight gain.
|
16 |
17614271
|
After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor alpha (TNF-alpha), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased.
|
17 |
18435774
|
Adiponectin concentrations remained unchanged during beta-adrenergic stimulation in both groups. beta-Adrenergic stimulation increased IL-6 concentration, which was more pronounced in the obese (p = 0.01 vs. lean).
|
18 |
19442860
|
Adiponectin level and Gutt's index decreased, but IL-6 level and ACR increased gradually among NGT, PD and NDDM groups (P<0.01).
|
19 |
19506327
|
This improved glycemic control, reduced daily insulin requirement, decreased IL-6 and hs-CRP levels rapidly and increased adiponectin level at 10 days after initiation of therapy.
|
20 |
20525188
|
Obese participants as well as individuals with elevated glycosylated hemoglobin, lower adiponectin, higher ferritin or with glutathione S-transferase M1 null genotype showed higher IL-6 effects.
|
21 |
20580627
|
Among non-obese persons, adiponectin correlated negatively with triglycerides (r=-0.280; adiponectin), IL-6 (r=-0.216; p<0.005), HOMA-IR (r=-0.373; p=000) and positively correlated with HDL (r=0.355; p=0.000).
|
22 |
20889139
|
At 3 months after periodontal intervention, the serum adiponectin levels were increased than those without periodontal intervention (all P<0.01), while CRP, IL-6 and TNF-? significantly decreased (all P<0.05) in both IGT and DM1 groups.
|
23 |
20087882
|
Moreover, KMF increased mRNA expression and protein secretion of adiponectin, whereas mRNA expression and secretion of monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6) were decreased.
|
24 |
21179199
|
While leptin concentrations were not altered by inhibition of IL-6 signalling, adiponectin concentrations significantly increased.
|
25 |
21081706
|
Sitagliptin also reduced adipocyte mRNA expression of inflammatory genes, including IL-6, TNF?, IL-12(p35), and IL-12(p40), 2.5- to fivefold as well as 12-lipoxygenase protein expression.
|
26 |
20978825
|
Adiponectin reduced IL-6-induced CRP mRNA levels in HepG(2) cells and CRP protein secretion.
|
27 |
21448265
|
Upon lipopolysaccharide stimulation, most of these adipocyte-associated cytokines/chemokines and immune cell modulating receptors were up-regulated and a few down-regulated such as (ICAM-1, VCAM-1, MCP-1, IP-10, IL-6, IL-8, TNF-? and TNF-? highly up-regulated and IL-2, IL-7, IL-10, IL-13 and VEGF down-regulated.
|
28 |
21459325
|
Surprisingly, this activation is associated with IL-6 production from macrophages induced by adiponectin through NF?B activation independent of its authentic receptors, AdipoR1 and AdipoR2.
|
29 |
21459325
|
These data have unraveled an insulin-sensitizing action initiated by adiponectin leading to upregulation of hepatic IRS-2 via an IL-6 dependent pathway through a still unidentified adiponectin receptor.
|
30 |
21205225
|
The MSG increased mRNA expression of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF?), resistin and leptin, but adiponectin did not exhibit any changes.
|
31 |
21424113
|
Furthermore, overexpression of PKCµ in 3T3-L1 adipocytes, but not other PKC isoforms, positively regulated the mRNA expression and promoter activity of MCP-1 and IL-6, and negatively regulated those of adiponectin.
|
32 |
21558084
|
When both conditions were present, HBP and obesity had additive associations with the expected geometric mean ratios for IL-6 (1.44, 95% CI 1.18 to 1.75), TNF-? (1.31, 95% CI 1.11 to 1.53), hsCRP (2.55, 95% CI 1.99 to 3.26) and negative association with adiponectin (0.61, 95% CI 0.52 to 0.71).
|
33 |
20460954
|
HOMA-IR was associated positively with BMI, waist circumference, serum NEFA, leptin, IL-6, and TNF-? levels, negatively with adiponectin, with no significant relation to resistin.
|
34 |
21478260
|
Treatment with RvD1 increased adiponectin production, while expression of IL-6 in adipose tissue was decreased.
|
35 |
21453187
|
Leptin, adiponectin, and adipsin did not correlate with the inflammatory cytokine IL-6 or with C-reactive protein (CRP).
|
36 |
21626471
|
Additionally, full length adiponectin was unable to abrogate LPS proinflammatory effect in TNF-? and IL-6 mRNA expression in CAD and NON-CAD macrophages.
|
37 |
21626471
|
In contrast, globular adiponectin appeared to have proinflammatory properties by potently upregulating TNF-? and IL-6 mRNA and protein secretion in human macrophages while subsequently rendered cells resistant to further proinflammatory stimuli.
|
38 |
21881808
|
On the other hand, sleep deprivation stress affects adipokines - increasing tumor necrosis factor-? (TNF-?) and interleukin-6 (IL-6) and decreasing leptin and adiponectin -, thus establishing a possible association between sleep-debt, adipokines and glucose metabolism.
|
39 |
21736771
|
Naringin significantly decreased IR, hyperinsulinaemia, hyperglycaemia, dyslipidaemia, TNF-?, IL-6, C-reactive protein and concomitantly increased adiponectin and ?-cell function in a dose-dependent manner.
|