Ignet

Gene Pair: INS, AHR

Related Sentences

#	PMID	Sentence
1	21849270	AhR signaling also affects molecular clock genes to influence glucose metabolism.Objective: We investigated mechanisms by which AhR activation affects glucose metabolism.Methods: Glucose tolerance, insulin resistance, and expression of peroxisome proliferator-activated receptor-? (PPAR-?) and genes affecting glucose metabolism or fatty acid oxidation and clock gene rhythms were investigated in wild-type (WT) and AhR-deficient [knockout (KO)] mice.
2	12970579	Despite these alterations in insulin regulation and responsiveness, pregnant AhR females did not have abnormal glucose tolerance tests and did not develop hyperglycemia, classic characteristics of gestational diabetes.
3	12970579	While the ultimate cause of the neonatal phenotype remains unclear, these studies establish that the AhR is required for normal insulin regulation in pregnant and older mice and for cardiac development in embryonic mice.
4	19623578	In conclusion, TCDD exposure impaired the second phase of glucose-stimulated secretion of insulin from the islets via the AhR signaling pathway.