Ignet

Gene Pair: INS, BTG2

Related Sentences

#	PMID	Sentence
1	8382698	The in vitro processing of mPOMC by the insulin secretory granule endopeptidase activity reported here is in excellent agreement with the in vivo processing of this prohormone by a combination of PC2 and PC3, candidates of prohormone endpeptidase, in gene transfer studies with cells that express the regulated secretory pathway (Thomas, L., Leduc, R., Thorne, B.
2	8138054	PC3 cleaves proinsulin first to generate a proinsulin conversion intermediate that is the preferred substrate of PC2.
3	8138054	Both PC2 and PC3 activities are influenced by Ca2+ and pH, but the more stringent Ca2+ and pH requirements of PC3 suggest it as the most likely enzyme to regulate proinsulin conversion, as well as initiate it.