Ignet

Gene Pair: INS, CDK5

Related Sentences

#	PMID	Sentence
1	14976144	Functional studies show that p35 stimulates the activity of the insulin promoter and that the stimulation requires CDK5 because stimulation is blocked by roscovitine, an inhibitor of CDK5 activity, a dominant negative form of CDK5, and small interfering RNAs against p35.
2	16887799	Inhibition of CDK5 prevented this decrease of insulin gene expression.
3	21151568	Our results indicate that CDKAL1 controls first-phase insulin exocytosis in ? cells by facilitating ATP generation, K(ATP) channel responsiveness and the subsequent activity of Ca(2+) channels through pathways other than CDK5-mediated regulation.
4	21611789	The diabetogenic role of CDKAL1 variants is suggested to consist in lower insulin secretion probably due to the insufficient inhibition of the CDK5 activity.
5	22028710	Inhibition of CDK5 averts the decrease of insulin gene expression through the inhibition of nuclear translocation of PDX-1 which is a transcription factor for the insulin gene.