Ignet

Gene Pair Information

Gene Pair: INS, COL1A1

Related Sentences

#	PMID	Sentence
1	3908487	Combinations of PDGF and insulin caused an even more rapid increase in collagen deposition.
2	4092861	Type IV collagen antigen crossreacting with antibodies to the C-terminal domain was elevated from 32.0 +/- 5.36 ng/ml (n = 10) in serum of normal rats to 94.9 +/- 24.5 ng/ml (n = 10, P less than 0.0001) in serum of streptozotocin diabetic rats and could be normalized to 40.1 +/- 8.30 ng/ml (n = 18) by insulin treatment.
3	3230579	An increase in the capacity of serum IgG to bind to native type IV collagen was observed in patients with both insulin-dependent and non insulin-dependent diabetes mellitus.
4	1695314	Therefore, the effects of isradipine, a new calcium antagonist, on glucose tolerance and insulin secretion during a 75-g oral glucose tolerance test (OGTT) and on ADP- and collagen-induced maximum first-wave platelet aggregation (Tmax%) were studied in 11 type II diabetic patients with borderline hypertension.
5	2164373	The individual effects of insulin and EGF added synergistically for a net gain in wound collagen content after 15 days.
6	1535382	Insulin was able to prevent all of the observed changes while aminoguanidine protected against changes in accumulation of advanced glycosylation end products and resistance to enzymatic digestion but not against changes in collagen concentration.
7	8262324	Insulin-like growth factor I and aldosterone, on the other hand, also increased glucose consumption but brought about an enhancement of only type IV collagen production, suggesting that the two collagens are independently regulated.
8	9388374	Levels of collagen alpha1(1) mRNA were also increased by both insulin and IGF-1.
9	9421397	Because ascorbate also influences osteoblast differentiation and is a cofactor for collagen synthesis, we examined the effects of insulin on the transport and metabolism of vitamin C in osteoblastic cells.
10	9795371	In the diabetic patients, we further determined serum levels of proinsulin, intact parathyroid hormone (PTH), 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and several biochemical bone markers, including osteocalcin (OSC), bone alkaline phosphatase (B-ALP), carboxy-terminal propeptide of type I procollagen (PICP), and type I collagen cross-linked carboxy-terminal telopeptide (ICTP).
11	14517715	Diabetes can impact bone through multiple pathways, some with contradictory effects, including obesity, changes in insulin levels, higher concentrations of advanced glycation end products in collagen, hypercalciuria associated with glycosuria, reduced renal function, lower insulin-like growth factor-I, microangiopathy, and inflammation.
12	16339499	Here we show in patients with type 2 diabetes mellitus (DM2) that platelets have lost responsiveness to insulin leading to increased adhesion, aggregation, and procoagulant activity on contact with collagen.
13	17003336	The integrin-dependent adhesion of fetal beta-cells to both collagen IV and vitronectin induces significant glucose-independent insulin secretion and a substantial reciprocal decline in insulin content.
14	17003336	Using real-time PCR, we demonstrate that adhesion of both fetal and adult beta-cells to collagen IV and vitronectin also results in the marked suppression of insulin gene transcription.
15	18333795	Isolated islets were placed in collagen gels, and they exhibited fourfold more insulin release than islets not in collagen.
16	18333795	The insulin released by beta-cells in islets encapsulated in collagen exhibited unobstructed diffusion within the collagen gels.
17	18485147	Moreover, a daily administration of nonglucidic nutrient EMS and metformin significantly decreased the levels of glucose, glycated hemoglobin, hydroxyproline, collagen content, extent glycation, fluorescence, neutral salt, acid and pepsin soluble collagen content, whereas it increased insulin, hemoglobin levels in diabetic rats.
18	19841616	We report that curcumin dose-dependently eliminates insulin-induced HSC activation by suppressing expression of type I collagen gene and other key genes relevant to HSC activation.
19	21325461	However, measures of insulin sensitivity (glucose infusion and disappearance rates) correlated positively with C-terminal telopeptide of type I collagen levels.
20	11697865	We observed an increased mRNA expression of insulin, proendocrine gene neurogenin 3, and beta-cell transcription factor Pdx1 when the cells were grown on bovine collagen I gels.