Ignet

Gene Pair: INS, CYCS

Related Sentences

#	PMID	Sentence
1	7556873	Insulin secretion from intact islets in response to glucose, glyceraldehyde, succinate monomethylester and tetramethyl p-phenylenediamine, which reduces cytochrome c directly, was significantly impaired in GK rats compared to control rats (P < 0.05, P < 0.01, P < 0.05 and P < 0.05, respectively).
2	16873683	Perforin and granzyme B impaired insulin secretion from islet cells, and this was accompanied by cytochrome c release, caspase activation, and DNA fragmentation.
3	21289215	Induction of diabetes also increased phosphorylation of tuberin in association with mTOR activation (measured by p70S6K phosphorylation), inactivation of Bcl-2, increased cytosolic cytochrome c expression, activation of caspase 3, and cleavage of PARP; insulin treatment prevented these changes.
4	21161439	Linoleic acid also dose-dependently reduced mitochondrial membrane potential (??m) and significantly promoted cytochrome c release from mitochondria in both 11.1�mM glucose and 25�mM glucose culture medium, further reducing glucose-stimulated insulin secretion, which is dependent on normal mitochondrial function.