Ignet

Gene Pair Information

Gene Pair: INS, EGF

Related Sentences

#	PMID	Sentence
1	6380310	Addition of 1 microM insulin during the culture period led to a 30% decrease in subsequent 125I-insulin binding; the presence or absence of either epidermal growth factor or carbachol was without effect on insulin binding.
2	3530724	The receptors were highly specific for insulin, with 60% inhibition of insulin binding by an antireceptor antibody, no competition by epidermal growth factor, and an ED50 of 300 nM for proinsulin.
3	2950929	Serum EGF concentrations measured were almost the same among the control, diabetic, and insulin-treated diabetic groups.
4	2950929	These results suggest that insulin deficiency in vivo causes a decrease in hepatic EGF receptors.
5	2957293	Serum EGF concentrations measured were almost the same among the control, diabetic, and insulin-treated diabetic groups.
6	2957293	These results suggest that insulin deficiency in vivo causes a decrease in hepatic EGF receptors.
7	2833110	To determine if other tyrosine kinases might be altered, we have studied the epidermal growth factor (EGF) receptor kinase in wheat germ agglutinin-purified, Triton X-100-solubilized liver membranes from streptozotocin (STZ)-induced diabetic rats and the insulin-deficient BB rat.
8	2833110	Thus autophosphorylation of EGF receptor, like that of the insulin receptor, is decreased in insulin-deficient rat liver.
9	2458910	Dexamethasone-induced changes in insulin and epidermal growth factor (EGF) receptor number, autophosphorylation, and kinase activity were studied in intact rat hepatocytes.
10	2647487	Production of milk proteins can be induced in vitro by the synergistic interactions of prolactin, insulin, and glucocorticoids and is inhibited by EGF and progesterone.
11	2525915	Daily administration of insulin to the streptozotocin-induced diabetic mice increased the hepatic levels of EGF receptor messenger RNAs to almost normal levels.
12	2525915	These results indicate that EGF binding to its receptor decreases in the liver of diabetic mice, involving alterations in the level of EGF receptor messenger RNAs, and that insulin is important for the regulation of EGF receptor gene expression in the liver but not in the kidney.
13	2164373	All groups that received insulin had lower collagenase activity than both controls and diabetic rats that received EGF.
14	2200528	FGF responses were abolished, EGF responses were partially inhibited, whereas the response to insulin was unaffected.
15	1766505	Urine EGF was 119 +/- 7.9 ng/day at day 7 in the control rats but it was significantly increased from day 2 in the diabetic rats (320 +/- 52.9 ng/day at day 2 and 298 +/- 18.4 ng/day at day 7), while in the insulin-treated rats it was significantly less than that in the diabetic rats (134 +/- 8.34 ng/day at day 2 and 220 +/- 15.2 ng/day at day 7).
16	8253016	On day 16 the EGF concentration in milk was significantly increased in insulin-treated rats, as compared to controls [2.66 (1.40-5.08) nM vs. 1.98 (1.04-3.16) nM].
17	8134187	These results indicate that insulin deficiency in lactating rats causes a decrease in the lactational performance and in the EGF content of milk.
18	8910437	However, Grb2 association with IRS-1 could not be detected in the basal or insulin-stimulated states, and mitogen-activated protein kinase (MAPK) activity could not be stimulated by insulin, epidermal growth factor, or platelet-derived growth factor.
19	12138086	The ability of the growth factors epidermal growth factor (EGF), transforming growth factor alpha, and platelet-derived growth factor to exert insulin-like effects on glucose transport and lipolysis were examined in human and rat fat cells.
20	12138086	No effects were found in rat fat cells, whereas EGF (EC(50) for glucose transport approximately 0.02 nm) and transforming growth factor alpha (EC(50) approximately 0.2 nm), but not platelet-derived growth factor, mimicked the effects of insulin (EC(50) approximately 0.2 nm) on both pathways.
21	12138086	EGF mimics the effects of insulin on both the metabolic and mitogenic pathways but utilize in part different signaling pathways.
22	12688387	The present study aimed to determine whether pharmacological treatment with gastrin and EGF can significantly stimulate beta-cell regeneration in chronic, severe insulin-dependent diabetes.
23	16514419	Inhibition of EGF and LIF signalling by pharmacological antagonists of the JAK2/STAT3 pathway, or knockdown of Ngn3 by RNA interference prevented the generation of new insulin-positive cells.
24	18053093	However, the role of EGF in regulating the major function of the pancreas, insulin secretion, has not been studied.
25	18053093	Here, we show that EGF rapidly increased insulin secretion in mouse pancreatic islets, as well as in a pancreatic beta-cell line.
26	18053093	In addition, EGF also increased plasma insulin levels and mediated glucose lowering in normal and diabetic mice.
27	19896952	Furthermore, IDE exhibits a remarkable ability to preferentially degrade structurally similar peptides such as the selective degradation of insulin-like growth factor (IGF)-II and transforming growth factor-alpha (TGF-alpha) over IGF-I and epidermal growth factor, respectively.
28	15769977	Gastrin, alone or in combination with EGF, but not EGF alone, increased the expression of pancreatic and duodenal homeobox factor-1 as well as insulin and C peptide in the cytokeratin 19-positive duct cells.