Ignet

Gene Pair: INS, EIF2AK3

Related Sentences

#	PMID	Sentence
1	16246168	Mice devoid of the eIF2 kinase GCN2 [general control non-derepressible-2 or EIF2AK4 (eIF2alpha kinase 4)] show sensitivity to nutritional deficiencies and aberrant eating behaviours, and deletion of PEK [pancreatic eIF2alpha kinase or PERK (RNA-dependent protein kinase-like endoplasmic reticulum kinase) or EIF2AK3] leads to neonatal insulin-dependent diabetes, epiphyseal dysplasia and hepatic and renal complications.
2	21029300	This review highlights the particular importance of PERK-mediated translational control and the transcriptional response in pancreatic ?-cells and how these relate to the highly specialized function of ?-cells, namely glucose-regulated insulin secretion and production.
3	20850340	Genetic and cellular studies of Perk-deficient beta cells showed that PERK was crucially required for ER functions including proinsulin trafficking and quality control, unrelated to the ER stress pathway.
4	20829802	Deficiency of PERK attenuates FFA-induced activation of IKK? and deficiency of IKK? alleviates FFA-induced inflammation and insulin resistance.
5	21624209	Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disorder characterized by the association of permanent neonatal or early-infancy insulin-dependent diabetes, multiple epiphyseal dysplasia and growth retardation, and other variable multisystem clinical manifestations.