Ignet

Gene Pair Information

Gene Pair: INS, FGF21

Related Sentences

#	PMID	Sentence
1	18252893	Fibroblast growth factor 21 (FGF21) is a metabolic regulator with multiple beneficial effects on glucose homeostasis and insulin sensitivity in animal models.
2	18252893	Serum FGF21 correlated positively with adiposity, fasting insulin, and triglycerides but negatively with HDL cholesterol, after adjusting for age and BMI.
3	19720803	Fibroblast growth factor-21 (FGF-21) is a potent metabolic regulator, which in animal models has been shown to improve glucose metabolism and insulin sensitivity.
4	19720803	Recently, FGF-21 was shown to be expressed and secreted from murine muscle cells in response to insulin stimulation.
5	19720803	Furthermore, we investigated systemic levels and muscle FGF-21 expression in humans with or without insulin resistance and chronic elevated insulin.
6	19720803	After 3 or 4 h of insulin infusion during a hyperinsulinemic-euglycemic clamp, muscular FGF-21 expression increased significantly.
7	19720803	In individuals with chronic elevated insulin, muscular FGF-21 expression was associated with hyperinsulinemia in men but not in women.
8	19699495	Fibroblast growth factor 21 (FGF21) has beneficial effects on glucose homeostasis and insulin sensitivity.
9	20424140	Interestingly, a mild elevation of FFAs resulting from complete insulin deficiency also increased FGF-21 levels.
10	20424140	These results from two independent human RCTs suggest that FFAs increase circulating FGF-21, while insulin is only of minor importance under physiological conditions.
11	20357365	Despite unchanged body fat content, rats treated with intracerebroventricular FGF21 displayed a robust increase of insulin sensitivity due to increased insulin-induced suppression of both hepatic glucose production and gluconeogenic gene expression, with no change of glucose utilization.
12	19906798	Pharmacologic studies show that FGF21 has broad metabolic actions in obese rodents and primates that include enhancing insulin sensitivity, decreasing triglyceride concentrations, and causing weight loss.
13	21309058	FGF21 exposure increased basal and insulin-stimulated glucose uptake in human myotubes, coincident with increased glucose transporter 1 mRNA, and enhanced glucose transporter 1 abundance at the plasma membrane.
14	21309058	In isolated extensor digitorum longus muscle, FGF21 potentiated insulin-stimulated glucose transport, without altering phosphorylation of Akt or AMP-activated protein kinase.
15	18840786	FGF21 also reduced blood glucose, insulin, and lipid levels and reversed hepatic steatosis.
16	18460341	Via reduced release of fatty acids into the circulation, the anti-lipolytic effect could be a mechanism through which FGF21 promotes insulin sensitivity in man.
17	22046277	The changes in plasma FGF-21 levels (?FGF-21) were positively associated with the amelioration of insulin resistance shown by the changes in M value.
18	21973233	Fasting serum FGF-21 was found to correlate positively and significantly with age, waist-to-hip ratio, systolic blood pressure, fasting plasma glucose, glycosylated hemoglobin A1c, homeostasis model assessment (HOMA) of insulin resistance, and hsCRP, but negatively with HOMA of ?-cell insulin secretion.