Ignet

Gene Pair: INS, FOXO6

Related Sentences

#	PMID	Sentence
1	21940782	FoxO6 integrates insulin signaling to hepatic gluconeogenesis.
2	21940782	Insulin inhibits FoxO6 activity via a distinct mechanism by inducing its phosphorylation and disabling its transcriptional activity, without altering its subcellular distribution in hepatocytes.
3	21940782	Our data uncover a FoxO6-dependent pathway by which the liver orchestrates insulin regulation of gluconeogenesis, providing the proof-of-concept that selective FoxO6 inhibition is beneficial for curbing excessive hepatic glucose production and improving glycemic control in diabetes.