Ignet

Gene Pair: INS, GLIS3

Related Sentences

#	PMID	Sentence
1	19264802	Our aim was to examine the role of Glis3 in beta cells, specifically with regard to regulation of insulin gene transcription.
2	19264802	We demonstrate that insulin 2 (Ins2) mRNA expression in rat insulinoma 832/13 cells is markedly increased by wild-type Glis3 overexpression, but not by the NDH1 mutant.
3	19264802	Glis3 also may indirectly affect insulin promoter activity through upregulation of MafA and downregulation of Nkx6-1.
4	19264802	This study uncovers a role of Glis3 for regulation of insulin gene expression and expands our understanding of its role in the beta cell.
5	19805515	In addition, we provide evidence that Glis3 regulates insulin gene expression through two Glis-binding sites in its proximal promoter, indicating that Glis3 also regulates beta-cell function.
6	20865670	Glis3 plays a key role in pancreatic development, particularly in the generation of �-cells and in the regulation of insulin gene expression.
7	21543335	Recently, Glis3 has been linked to both type I and type II diabetes and shown to positively regulate insulin gene expression.