Ignet

Gene Pair: INS, GRB10

Related Sentences

#	PMID	Sentence
1	8621530	Glutathione S-transferase fusion proteins containing the Grb10 SH2 domain associated in an insulin-dependent manner with insulin receptors from cell lysates and with purified insulin receptors.
2	9062339	Hormone-activated insulin receptors in R-IR cells coprecipitated with three species, all recognized as Grb10 isoforms by specific Grb10 antibody.
3	9062339	In conclusion, Grb10 interacts preferentially with insulin vs.
4	11181517	IRBP binding to region V was competed by VmSp1, but not by VmAT, indicating specific interactions with the AT-rich sequence; insulin response elements from other genes also failed to compete.
5	11181517	IRBP responded to as little as 10(-10) M insulin, indicating physiological relevance.
6	11181517	As most insulin-responsive genes do not exhibit insulin-responsive nuclear factor binding, further studies of IRBP may also contribute to understanding of the mechanism of insulin action on gene transcription.
7	11457835	These findings indicate that the presence of the AT-rich element is essential for the actions of Sp1 in vitro and in vivo, and the combination of both spacing requirements and insulin responsiveness suggests that IRBP may interact directly with Sp1.
8	19789144	The GRB10 protein binds to insulin and insulin-like growth factor receptors and acts as a negative regulatory protein.