Ignet

Gene Pair: INS, HSPA5

Related Sentences

#	PMID	Sentence
1	19103594	Overexpressing the ER chaperone GRP78 partially rescued high glucose-induced suppression of proinsulin levels and improved glucose-stimulated insulin secretion with no effect on insulin 2 mRNA levels.
2	19103594	Knockdown of GRP78 expression under basal glucose conditions reduced cellular insulin levels and glucose-stimulated insulin secretion.
3	20839851	Key alterations included inhibition of insulin translation and post-translational modifications in ER chaperones HYOU1 and HSPA5.
4	21784843	Rat insulin 2 promoter-DN HNF1? mouse islets express lower levels of BiP mRNA, synthesize less insulin, and are sensitized to ER stress relative to matched control mouse islets, suggesting that this mechanism is also operating in vivo.