Ignet

Gene Pair: INS, ISL1

Related Sentences

#	PMID	Sentence
1	8425669	IAPP at 10(-7) M reduced insulin release by 32% from 7.1 (95% Cl 5.8-8.6) to 4.8 (3.0-7.5) fmol.min-1 x islet-1 (P = 0.046, n = 7).
2	8425669	IAPP at 1.5 x 10(-6) M reduced insulin release by 62% from 6.5 (3.4-12.3) to 2.5 (1.4-4.4) fmol.min-1 x islet-1 (P = 0.001, n = 6).
3	7912209	The islet-1 (Isl-1) gene encodes a protein that binds to the enhancer region of the insulin gene.
4	7789634	Islet-1 (Isl-1) is a unique transcription factor that binds to the enhancer region of the insulin gene.
5	11978636	In fact, overexpression of both Pdx-1 and Isl-1 in IEC-6 cells (Isl-YK-12, -14, and -15 cells) gave them the ability to express insulin without exposure to betacellulin.
6	17022998	Here, we showed that Isl1 could enhance the HNF4alpha-mediated activation of transcription of the HNF1alpha, PPARalpha and insulin I promoters.
7	21099304	We have also identified MafA, a potent Insulin gene regulator, as the first direct target of Isl-1 in ?-cells.
8	15561947	We do not however find any expression of the late-stage genes (Pax4, Pax6, Isl-1, and MafA) related to beta-cell development, and the cells do not secrete insulin upon the glucose challenge.