Ignet

Gene Pair: INS, NEU1

Related Sentences

#	PMID	Sentence
1	3407769	Adipocytes treated with neuraminidase show markedly reduced responsiveness to insulin without any alteration in insulin binding.
2	3407769	At a concentration of neuraminidase that decreases insulin action by 50%, 23% of total cellular sialic acid content was released.
3	2666202	The enzyme action on glucose transport was not due to a nonspecific membrane perturbation because neuraminidase caused only a nonsignificant decrease in the uptake of the amino acid analog alpha-(methylamino)isobutyric acid and had no effect on basal or insulin-stimulated protein synthesis.
4	2666202	Insulin binding was slightly increased in neuraminidase-treated cells, yet the shapes of the dose-response curves for insulin stimulation of glucose transport were similar (EC50 = 0.087 +/- 0.010 and 0.082 +/- 0.008 nM for control and treated cells, respectively).
5	1727740	Furthermore, liver binding data were not due to cross-reaction of 125I-labeled insulin to the insulinlike growth factor I receptor, and treatment of liver membranes with neuraminidase did not alter the inhibitory effect of the IgGa fraction from patient I-2 on 125I-labeled insulin binding to liver.