Ignet

Gene Pair Information

Gene Pair: INS, PDK4

Related Sentences

#	PMID	Sentence
1	9405294	Re-feeding of starved rats and insulin treatment of diabetic rats very effectively reversed the increase in PDK4 protein and restored PDK enzyme activity to levels of chow-fed control rats.
2	15026305	In contrast, PDK-4 mRNA level was decreased 72% by insulin (P < 0.05), and Intralipid infusion prevented only 20% of the decrease.
3	15026305	PDK-4 protein level was decreased approximately 20% by insulin (P < 0.05), but this effect was not altered by Intralipid infusion.
4	15026305	In conclusion, the present data indicate that insulin had a profound effect to suppress PDK-4 expression in skeletal muscle and that, contrary to previous suggestions, circulating FFA had little impact on PDK-4 mRNA expression, at least within 5 h.
5	16873695	In the present study, we examined whether insulin's effect on PDK4 expression is impaired in acute insulin-resistant states and, if so, whether this change is accompanied by decreased insulin's effects to stimulate Akt and forkhead box class O (FOXO) 1 phosphorylation.
6	16873695	These data suggest that insulin's effect to suppress PDK4 gene expression in skeletal muscle is impaired in insulin-resistant states, and this may be due to impaired insulin signaling for stimulation of Akt and FOXO1 phosphorylation.
7	17363743	In cardiomyocytes, PKC inhibition attenuated fatty acid-induced increases in the metabolic genes PDK4 and UCP3 and also prevented fatty acid-mediated inhibition of basal and insulin-stimulated glucose oxidation.
8	21162119	Factors that regulate PDK4 mRNA expression include plasma corticosterone, insulin and free fatty acids.
9	18769905	Overexpression of PC in INS-1 cells led to an elevation of insulin secretion and cell proliferation, whereas inhibition of PDH activity by overexpressing Pdk4 in INS-1 cells did not reduce insulin secretion.
10	21615395	However, GW501516-mediated fold increments in PDK4 and ANGPTL4 expression, reflecting PPAR? responsiveness, were positively associated with donors' insulin sensitivity derived from OGTT (P?=?0�0182 and P?=?0�0231, respectively) and hyperinsulinemic-euglycemic clamp (P?=?0�0046 and P?=?0�0258, respectively).