Ignet

Gene Pair: INS, PKNOX1

Related Sentences

#	PMID	Sentence
1	18644868	Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance.
2	18644868	We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway.
3	20864515	Prep1 overexpression in HepG2 liver cells upregulated SYP and SHP1 and inhibited insulin-induced IR and IRS1/2 phosphorylation and was accompanied by reduced glycogen content.
4	20864515	In Prep1 overexpressing cells, antisense silencing of SHP1, but not that of SYP, rescued insulin-dependent IR phosphorylation and glycogen accumulation.
5	20864515	SHP1, a known silencer of insulin signal, is a transcriptional target of Prep1.
6	20864515	In liver, transcriptional activation of SHP1 gene by Prep1 attenuates insulin signal transduction and reduces glucose storage.