Ignet

Gene Pair: INS, PLA2G6

Related Sentences

#	PMID	Sentence
1	15471944	Islet Ca2+-independent phospholipase A2 (iPLA2) is postulated to mediate insulin secretion by releasing arachidonic acid in response to insulin secretagogues.
2	15471944	However, the significance of iPLA2 signaling in insulin secretion in vivo remains unexplored.
3	15471944	Bromoenol lactone (BEL), a selective inhibitor of iPLA2, inhibited glucose-stimulated insulin secretion from isolated mouse islets; this inhibition was overcome by exogenous arachidonic acid.
4	15471944	These results unambiguously demonstrate that iPLA2 signaling plays an important role in glucose-stimulated insulin secretion under physiological conditions.