Ignet

Gene Pair Information

Gene Pair: INS, PNPLA3

Related Sentences

#	PMID	Sentence
1	16380488	These data suggest that murine ATGL but not adiponutrin contributes to net adipocyte lipolysis and that ATGL and adiponutrin are oppositely regulated by insulin both in vitro and in vivo.
2	16505250	Visceral ADPN mRNA expression was correlated to measures of insulin sensitivity (fasting insulin and homeostasis model assessment).
3	16914601	The purpose of the present work was to get more insight into the regulation of adiponutrin gene expression by insulin and/or glucose using clamp studies and to examine its potential dysregulation in subjects with a deterioration of glucose homeostasis.
4	16914601	Adiponutrin gene expression was also analyzed in patients with different levels of insulin resistance.
5	16914601	Infusion of both insulin and glucose (HGHI) had an additive effect on the adiponutrin expression (tenfold, P = 0.008).
6	17088412	In healthy young men, adiponutrin expression is upregulated [corrected] by hyperinsulinemia and is related to basal and/or insulin-stimulated p85alpha PI3K, HKII, adiponectin, and leptin expression levels.
7	17088412	We hypothesize that insulin-mediated regulation of adiponutrin expression is under the PI3K pathway.
8	19651814	In a genome-wide association scan, the rs738409 C>G single nucleotide polymorphism (SNP) in the patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with increased liver fat but not with insulin resistance estimated from fasting values.
9	20648554	Polymorphisms in PNPLA3 have been linked to obesity and insulin sensitivity.
10	20648554	CONCLUSION: Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin resistance in mice.
11	21319195	The rs738409 C>G patatin-like phospholipase domain-containing 3 (PNPLA3) single nucleotide polymorphism (SNP), encoding for the I148M protein variant, influences liver fat without affecting insulin resistance and body composition.