Ignet

Gene Pair Information

Gene Pair: INS, RETN

Related Sentences

#	PMID	Sentence
1	11201732	Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action.
2	11373275	Elevated levels of the hormone resistin, which is secreted by fat cells, are proposed to cause insulin resistance and to serve as a link between obesity and type 2 diabetes.
3	11809189	Resistin, an adipocyte-derived cytokine, causes insulin resistance and glucose intolerance in mice.
4	12660880	Resistin treatment impaired glucose tolerance and insulin action.
5	12814870	The protein hormone, resistin, secreted specifically by the adipose tissues, is found to antagonize insulin action upon glucose uptake and may serve as an important role between human obesity and insulin resistance.
6	14550293	Therefore, caution should be exercised in interpreting resistin as a link between obesity and insulin resistance in humans.
7	14962997	Resistin is an adipose-derived hormone that has been proposed as a link among obesity, insulin resistance, and diabetes.
8	15024400	Taken collectively, plasma resistin concentration, before and after PIO treatment, correlated positively with hepatic fat content (r=0.66, P<0.001) and EGP during the insulin clamp (r=0.41, P<0.05).
9	15024400	However, the plasma resistin concentration did not correlate with whole body glucose disposal (Rd) during the insulin clamp either before (r=-0.18, P=NS) or after (r=-0.13, P=NS) PIO treatment.
10	15024400	The decrease in plasma resistin is positively correlated with the decrease in hepatic fat content and improvement in hepatic insulin sensitivity.
11	15155948	Infusion of a resistin mutant, lacking the intertrimer disulfide bonds, in pancreatic-insulin clamp studies reveals substantially more potent effects on hepatic insulin sensitivity than those observed with wild-type resistin.
12	15522996	Resistin is an adipocyte-secreted hormone proposed to link obesity with insulin resistance and diabetes, but no previous study has performed a joint quantitative evaluation of white adipose tissue (WAT) resistin mRNA expression and serum levels in relation to insulinemia and glycemia in mice.
13	15522996	In addition, serum resistin levels, but not resistin mRNA expression levels, are correlated with body weight, and neither resistin mRNA expression nor serum resistin levels are correlated with serum insulin or glucose levels.
14	15585589	Resistin (Rstn) is known as an adipocyte-specific secretory factor that can cause insulin resistance and decrease adipocyte differentiation.
15	15864531	Resistin is an adipokine that might link obesity and insulin resistance.
16	15928242	Resistin appears to be not the main link between obesity and insulin resistance in children and adolescents but because of its association with Tanner stage, it may be related to the maturation of children during pubertal development.
17	16080635	It is suggested that circulating resistin levels are not associated with obesity or insulin resistance in humans.
18	16087164	Resistin, secreted from adipocytes, causes insulin resistance in rodents.
19	16493877	Resistin and TNF-alpha positively correlated with each other, insulin, HOMA, and negatively with ghrelin.
20	16367888	Resistin 1 microm significantly reduced maximum insulin-stimulated 2-deoxyglucose uptake in L6 cells from 634 to 383% (relative to 100% for control, p < 0.001), and co-administration of rosiglitazone had no effect on resistin-induced insulin resistance.
21	16367888	In the absence of insulin, however, resistin increased glucose uptake dose-dependently (e.g., 1.75-fold at 5 microm, p < 0.001) via a mitogen-activated protein kinase-dependent pathway.
22	16367888	These results demonstrate that various glucose-lowering therapies and oleic acid reduce resistin gene expression in isolated adipocytes, and that resistin impairs insulin-stimulated glucose uptake in skeletal muscle-derived cells.
23	16159906	Resistin (Rstn) is known as an adipocyte-specific secretory hormone that can cause insulin resistance and decrease adipocyte differentiation.
24	16341686	Insulin-stimulated oxidation of glucose via the Krebs cycle was reduced by resistin, whereas lactate production was unaltered.
25	16395259	In the present study, we explore the role of decreased renal function and a genetic polymorphism on the recently discovered protein resistin, apparently able to inhibit hepatic insulin action in mice.
26	16395259	However, in a multiple regression model, resistin, as well as all the measured markers of inflammation, was only associated with insulin resistance if GFR was not taken into account.
27	16625816	While in rodents resistin appears to have an important role in the development of liver insulin resistance, its role in humans is less clear, and it is probably involved in the regulation of inflammatory processes rather than in insulin sensitivity.
28	17048191	The result suggests that plasma resistin has a role in linking central obesity and obesity-related insulin resistance to type II diabetes mellitus.
29	17065346	Nevertheless, resistin deficiency improved glucose tolerance and insulin sensitivity in these severely obese mice, largely by enhancing insulin-mediated glucose disposal in muscle and adipose tissue.
30	17785630	Resistin, a recently discovered proinflammatory cytokine, has been variably associated with insulin resistance, inflammation, and renal dysfunction.
31	17893258	The expressions of both resistin and adiponectin in s.c. adipose tissue are stimulated by acute hyperinsulinaemia, whereas losartan attenuates their insulin-stimulated expressions.
32	17952831	In rodents, resistin is produced by adipose tissue, and is a significant regulator of glucose metabolism and insulin sensitivity.
33	17178123	Adiponectin and resistin are proteins that affect insulin resistance and atherosclerosis significantly.
34	17936398	Resistin was initially identified as a protein, secreted by adipocytes, which inhibits insulin action and adipose differentiation.
35	18180399	In vitro gene expression analysis in human coronary endothelial cells revealed that resistin induced fatty acid binding protein, a key molecule of insulin resistance, diabetes, and atherosclerosis.
36	18081734	Resistin, secreted from adipocytes, causes insulin resistance in rodents.
37	19125180	The corresponding plasma resistin levels were slightly, but not significantly, increased in DM2 women (P = .051), and overall, they correlated significantly with BMI (r = 0.406, P = .010) and waist circumference (r = 0.516, P = .003), but not with fasting insulin levels or HOMA-IR.
38	19126543	Resistin antagonizes insulin action in mouse, making it a potential therapeutic target for treating metabolic diseases such as diabetes.
39	18672341	Liver glycogen metabolism plays an essential role in maintaining glucose homeostasis, we investigated the effect of resistin on liver glycogen metabolism and attempted to identify its role in initiating insulin resistance and type 2 diabetes.
40	18672341	Hepatocytes exposed to resistin, but only in the presence of insulin, show a decrease in insulin-stimulated glycogen content.
41	18672341	These results strongly suggest that resistin effects glycogen metabolism at the protein level, and resistin is highly associated with insulin resistance and type 2 diabetes and is a candidate for the prevention and treatment of type 2 diabetes.
42	18839335	Resistin, an adipokine-linked obesity with type 2 diabetes, impairs glucose-stimulated insulin secretion (GSIS) in beta-cells.
43	19922611	Resistin, secreted from adipocytes, causes insulin resistance in mice.
44	19940327	Adipose tissue produces multiple cytokines(TNF-alpha, IL-6, PAI-1, CRP, angiotensinogen, leptin, adiponectin, visfatin, apelin, resistin)which decrease insulin sensitivity and induce inflammatory processes, endothelial dysfunction,and atherosclerosis.
45	19727657	Multiple linear regression analysis with adjustment for age and sex also showed that the plasma resistin level was significantly associated with serum concentrations of HDL-cholesterol, triacylglycerol and insulin, as well as with BMI.
46	19727657	In addition, plasma resistin level was associated with dyslipidaemia, serum insulin concentration and obesity.
47	20121885	Additionally, fasting plasma glucose, insulin and homeostatis model assessment of insulin resistance (HOMA-IR) significantly decreased while adiponectin increased over threefold [9.7 (3.7-17.7) vs. 38.0 (19.3-42.4) microg/ml] without any changes in resistin.
48	20819535	To evaluate the association between the four adipokines, adiponectin, leptin, resistin and tumor necrosis factor-alpha (TNF-alpha) with insulin sensitivity, we used a hyperinsulinemic euglycemic clamp to test insulin sensitivity in Chinese patients with obesity and type 1 or type 2 diabetes mellitus versus controls.
49	20699433	Insulin did not affect TNF-?, MCP-1, IL-6, LBP, resistin, and HMG-B1 increases induced by the LPS.
50	20300528	Resistin, secreted from adipocytes, causes insulin resistance in mice.
51	21159034	To investigate changes in maternal serum resistin levels during pregnancy and postpartum and clarify their relationship to insulin resistance.
52	21251282	Adiponectin and resistin are adipokines which modulate insulin action, energy, glucose and lipid homeostasis.
53	20827661	Moreover, serum resistin was not influenced by insulin resistance in either group examined.
54	15517149	Our results add to growing evidence that resistin is associated with variation in weight, fat distribution and insulin resistance.
55	21282361	Although adipocyte-derived murine resistin links insulin resistance to obesity, the role of human resistin, predominantly expressed in mononuclear cells and induced by inflammatory signals, remains unclear.
56	21282361	Thus, human resistin may link insulin resistance to inflammatory diseases such as obesity, type 2 diabetes, and atherosclerosis.
57	15983036	Murine resistin reduced insulin-stimulated glucose uptake, establishing the heart as a resistin target tissue.
58	15983036	Notably, human resistin also impaired insulin action in mouse cardiomyocytes, providing the first evidence that human and mouse resistin homologs have similar functions.
59	15983036	Remarkably, unlike native resistin, monomeric C26A resistin had no effect on basal or insulin-stimulated glucose uptake in mouse cardiomyocytes.
60	21181202	Downregulation of resistin and leptin gene expression after bariatric surgery may play a role in normalizing obesity-associated insulin resistance.
61	18710472	Resistin causes insulin resistance and diabetes in mice whereas in humans it is linked to inflammation and atherosclerosis.
62	21285283	These results suggest that with increasing age autocrine effects of resistin in fat tissue may predispose to diabetes in part by impairing insulin action in adipose tissue.
63	21694920	Fatty acid accumulation and resistin inhibit insulin and adiponectin.
64	21478152	Resistin has been suggested to be involved in the development of diabetes and insulin resistance.
65	21808585	Resistin, another protein secreted by the adipose tissue, derived its name due to its involvement in the development of insulin resistance.
66	21447495	However, in this group, serum resistin was not correlated with age, gender, body mass index (BMI), total cholesterol, FBG, insulin, CK, LDH, and the calculated homeostasis model for insulin resistance (HOMA-IR) (p>0.05).
67	21750415	An immunofluorescence technique was used to examine the expression of resistin and its co-localization with insulin and glucagon in pancreatic islet cells.
68	21750415	Resistin co-localized with insulin but not glucagon in pancreatic islet cells of both normal and diabetic patients.
69	21885493	Spearman correlations and multivariable regressions were used to examine whether resistin levels were associated with SLE, disease-specific and inflammatory markers, insulin resistance, and CAC.
70	21885493	Resistin level did not correlate with markers of insulin resistance or body adiposity, including homeostatic model assessment or BMI.
71	21885493	Among subjects with SLE, higher resistin level correlated positively with renal dysfunction, inflammatory markers, and disease damage but not with insulin resistance or BMI.
72	21995154	Resistin is a potent regulator of glucose homeostasis which is thought to oppose the action of insulin in peripheral tissues.