Ignet

Gene Pair: INS, SERPINA1

Related Sentences

#	PMID	Sentence
1	6788617	Using a high resolution automated chromatographic method, the levels of the different minor haemoglobins Hb A1a, A1b, and A1c were measured in 20 healthy controls, in 20 patients with chronic renal failure, in 20 uraemic patients on intermittent haemodialysis, and in 20 insulin-dependent diabetic patients.
2	20692406	We assessed the effects of A1AT supplementation (0.5 mg/mL; n = 4] on TCE activity, insulin levels, culture recovery, and islet quality.
3	20692406	Addition of A1AT to impure islet preparations reduced protease activity and restored normal insulin levels as detected using enzyme-linked immunosorbent assay (ELISA) and SDS-PAGE of culture supernates.
4	20692406	Culture of impure human islet fractions in the presence of A1AT prevented insulin cleavage and improved islet recovery.
5	21099312	We found that AAT increases insulin secretion in a glucose-dependent manner, potentiates the effect of GLP-1 and forskolin and neutralizes the inhibitory effect of clonidine on insulin secretion.
6	21099312	Our findings show that AAT stimulates insulin secretion and protects ?-cells against cytokine-induced apoptosis, and these effects of AAT seem to be mediated through the cAMP pathway.
7	21099312	In view of these novel findings we suggest that AAT may represent a novel anti-inflammatory compound to protect ?-cells under the immunological attack in T1D but also therapeutic strategy to potentiate insulin secretion in type 2 diabetes (T2D).