Ignet

Gene Pair Information

Gene Pair: INS, SERPINF1

Related Sentences

#	PMID	Sentence
1	19073347	In multiple regression analyses, BMI, age (inversely) and PEDF were independently correlated with homeostasis model assessment of insulin resistance (HOMA-IR).
2	20631025	We aimed to study circulating pigment epithelium-derived factor (PEDF) in vivo in association with insulin resistance and in vitro in human adipocytes.
3	20631025	In all subjects, PEDF was positively associated with body mass index (r = 0.326; P < 0.0001), waist-to-hip ratio (r = 0.380; P < 0.0001), HbA(1c), and fasting triglycerides and negatively with insulin sensitivity (r = -0.320; P < 0.0001).
4	20631025	Multiple linear regression analyses revealed that insulin sensitivity contributed independently to explain 14% of the variance in PEDF levels after controlling for the effects of body mass index, age, and log fasting triglycerides.
5	20631025	Circulating PEDF is associated with insulin sensitivity.
6	21464445	Pigment epithelium-derived factor (PEDF) is an adipocyte-secreted factor involved in the development of insulin resistance in obesity.
7	20938440	Treatment of adipocytes and hSkMC with PEDF induced insulin resistance in adipocytes, skeletal and smooth muscle cells at the level of insulin-stimulated Akt phosphorylation, which was dose dependent and more prominent in adipocytes.
8	20938440	PEDF is one of the most abundant adipokines and its secretion is inversely regulated by insulin and hypoxia.
9	20938440	PEDF induces insulin resistance in adipocytes and hSkMC and leads to inflammatory signaling in hSMC.