Ignet

Gene Pair: INS, SLC5A2

Related Sentences

#	PMID	Sentence
1	19232040	In animal models of DM, pharmaceutical inhibition of SGLT2 reduces hyperglycaemia, and may improve insulin resistance.
2	19852718	This capacity can be modulated by SGLT2 inhibitors thereby providing a unique insulin independent method of treatment of diabetes.
3	21105857	Dapagliflozin, a selective inhibitor of sodium glucose transporter 2 (SGLT2), targets hyperglycemia independently of insulin, via decreasing renal glucose reabsorption.
4	21358697	Consequently, SGLT2 inhibitors reduce plasma glucose insulin independently and improve insulin resistance in diabetes.
5	21358698	Animal studies suggest that reduction of hyperglycemia with SGLT2 inhibitors may also improve insulin sensitivity and preserve ?-cell function.
6	21357472	SGLT2 knockout mice were protected from HFD-induced hyperglycemia and glucose intolerance and had reduced plasma insulin concentrations compared with controls.
7	21357472	On the db/db background, SGLT2 deletion prevented fasting hyperglycemia, and plasma insulin levels were also dramatically improved.
8	21816980	Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduces hyperglycemia by increasing urinary glucose excretion independent of insulin and may cause fewer of these adverse effects.