Ignet

Gene Pair: IRS2, GCG

Related Sentences

#	PMID	Sentence
1	20849951	Importantly, recent studies found that ?-arrestin-1 mediates GLP-1 signalling to insulin secretion, GLP-1 antiapoptotic effect by phosphorylating the proapoptotic protein Bad through ERK1/2 activation, and PACAP potentiation of glucose-induced long-lasting ERK1/2 activation controlling IRS-2 expression.
2	21255808	Whereas palmitate significantly decreased the phosphorylation of IRS-2, PKB, and FoxO1 in MIN6 cells, these changes were significantly inhibited by treatment with GLP-1 and/or candesartan.
3	21255808	The present results suggest that GLP-1 and candesartan additively prevent glucolipotoxicity-induced apoptosis in pancreatic ?-cells through the IRS-2/phosphoinositide 3-kinase/PKB/FoxO1 signaling pathway.