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Gene Pair Information
Gene Pair: IRS2, SOCS1
Related Sentences
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PMID |
Sentence |
1 |
12228220
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We show that SOCS1 or SOCS3 targeted IRS1 and IRS2, two critical signaling molecules for insulin action, for ubiquitin-mediated degradation.
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2 |
12228220
|
SOCS1 or SOCS3 bound both recombinant and endogenous IRS1 and IRS2 and promoted their ubiquitination and subsequent degradation in multiple cell types.
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3 |
12228220
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Mutations in the conserved SOCS box of SOCS1 abrogated its interaction with the elongin BC ubiquitin-ligase complex without affecting its binding to IRS1 or IRS2.
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4 |
12228220
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The SOCS1 mutants also failed to promote the ubiquitination and degradation of either IRS1 or IRS2.
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5 |
12228220
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Adenoviral-mediated expression of SOCS1 in mouse liver dramatically reduced hepatic IRS1 and IRS2 protein levels and caused glucose intolerance; by contrast, expression of the SOCS1 mutants had no effect.
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