Ignet

Gene Pair: MAFA, MAPK1

Related Sentences

#	PMID	Sentence
1	19407223	We also show that the N-terminal domain of MafA plays a major role in p38 MAPK-mediated degradation; simultaneous mutation of both threonines 57 and 134 into alanines in MafA was sufficient to prevent this degradation.
2	19407223	Interestingly, inhibiting p38 MAPK but not glycogen synthase kinase 3 prevented oxidative stress-dependent degradation of MafA.
3	19407223	These results suggest that the p38 MAPK pathway may represent a common mechanism for regulating MafA levels under oxidative stress and basal and stimulatory glucose concentrations.
4	19407223	Therefore, preventing p38 MAPK-mediated degradation of MafA represents a novel approach to improve beta-cell function.