Ignet

Gene Pair: NOX5, NAMPT

Related Sentences

#	PMID	Sentence
1	22073309	In both cultured human umbilical vein endothelial cells and rat microvascular preparations, visfatin (50 ng/mL) stimulated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, as determined by lucigenin-derived chemiluminiscence.
2	22073309	The relaxation to ACh impaired by visfatin was restored by the NADPH oxidase inhibitor apocynin (10 �mol/L).
3	22073309	Accordingly, the product of Nampt activity nicotinamide mononucleotide (100 nmol/L to 1 mmol/L) stimulated endothelial NADPH oxidase activity and concentration-dependently impaired ACh-induced vasorelaxation.
4	22073309	In conclusion, visfatin impairs endothelium-dependent relaxation through a mechanism involving NADPH oxidase stimulation and relying on Nampt enzymatic activity, and therefore arises as a potential new player in the development of endothelial dysfunction.