Ignet

Gene Pair: PDCD1, PDCD1LG2

Related Sentences

#	PMID	Sentence
1	16517716	Programmed death-1 (PD-1) is a negative costimulatory molecule, and blocking the interaction of PD-1 with its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), enhances autoimmune disease in several animal models.
2	16517716	The strain-specific effects of PD-1 ligand blockade did not correlate with the expression of PD-L1 and PD-L2 on dendritic cells and macrophages in lymphoid tissue, or on inflammatory cells in the CNS.
3	16606670	PD-1 has two ligands: PD-1 ligand 1 (PD-L1), which is expressed broadly on hematopoietic and parenchymal cells, including pancreatic islet cells; and PD-L2, which is restricted to macrophages and dendritic cells.
4	18759926	Similarly, PD-1 interactions with PD-L1 and PD-L2 downmodulate T-cell immune responses.