Ignet

Gene Pair: PTGS2, S100B

Related Sentences

#	PMID	Sentence
1	18854308	We examined the molecular mechanisms by which the RAGE ligand, S100b, induces COX-2 in monocytes.
2	18854308	S100b significantly increased COX-2 mRNA accumulation in THP-1 monocytes at 2 h via mRNA stability.
3	18854308	Chromatin immunoprecipitation and RNA immunoprecipitation revealed that S100b decreased occupancy of the DNA/RNA-binding protein, heterogeneous nuclear ribonuclear protein K (hnRNPK), at the COX-2 promoter but simultaneously increased its binding to the COX-2 3'-UTR.
4	18854308	S100b treatment promoted the translocation of nuclear hnRNPK to cytoplasm, whereas a cytoplasmic translocation-deficient hnRNPK mutant inhibited S100b-induced COX-2 mRNA stability.
5	18854308	Furthermore, S100b significantly down-regulated the expression of a key microRNA, miR-16, which can destabilize COX-2 mRNA by binding to its 3'-UTR.